2 documents found, page 1 of 1
Hepatic wnt1 inducible signaling pathway protein 1 (WISP-1/CCN4) associates wit...
Pivovarova-Ramich, O; Loske, J; Hornemann, S; Markova, M; Seebeck, N; Rosenthal, A; Klauschen, F; Castro, JP; Buschow, R; Grune, T; Lange, VLiver fibrosis is a critical complication of obesity-induced fatty liver disease. Wnt1 inducible signaling pathway protein 1 (WISP1/CCN4), a novel adipokine associated with visceral obesity and insulin resistance, also contributes to lung and kidney fibrosis. The aim of the present study was to investigate the role of CCN4 in liver fibrosis in severe obesity. For this, human liver biopsies were collected from 3...
Non-enzymatic cleavage of Hsp90 by oxidative stress leads to actin aggregate fo...
Castro, JP; Fernando, R; Reeg, S; Meinl, W; Almeida, H; Grune, TAging is accompanied by the accumulation of oxidized proteins. To remove them, cells employ the proteasomal and autophagy-lysosomal systems; however, if the clearance rate is inferior to its formation, protein aggregates form as a hallmark of proteostasis loss. In cells, during stress conditions, actin aggregates accumulate leading to impaired proliferation and reduced proteasomal activity, as observed in cellu...