3 documents found, page 1 of 1
The influence of glutathione pathway modulators on the cytotoxicity of sunitini...
Vitorino-Oliveira, C.; Kahremany, S.; Nisim, L.; Duarte-Araújo, M.; Carvalho, F.; Gruzman, A.; Costa, V. M.Background: Cancer survivorship has grown over the years due to more efficacious treatments. Nonetheless, anticancer treatments present serious adverse effects, namely cardiotoxicity. Doxorubicin (DOX), a topoisomerase II inhibitor; sunitinib (SUN), a multikinase inhibitor; and bortezomib (BTZ), an inhibitor of proteasome, have their clinical use limited because of their cardiotoxicity. Cardiotoxicity is often ...
Gene silencing by siRNA nanoparticles synthesized via sonochemical method
Shimanovich, Ulyana; Munder, A.; Loureiro, Ana; Azóia, Nuno G.; Gomes, Andreia C; Paulo, Artur Cavaco; Gedanken, Aharon; Gruzman, A.The knowledge that small RNAs can affect gene expression has had a tremendous impact on basic and applied research, and gene silencing is currently one of the most promising new approaches for disease therapy. However, RNAs cannot easily penetrate cell membranes, therefore RNA delivery become one of the major challenges for gene silencing technology. In the current paper we discuss a general approach for conver...
Sonochemically-induced spectral shift as a probe of green fluorescent protein r...
Shimanovich, Ulyana; Munder, A.; Azóia, Nuno G.; Paulo, Artur Cavaco; Gruzman, A.; Knowles, T. P. J.; Gedanken, AharonEncapsulation in the form of micro and nanocapsules is an attractive route for controlling the delivery and release of active proteins and peptides. Many approaches exist to probe the morphology of such capsules as well as their mechanisms of formation. By contrast, the release of proteins from such components in a complex biological environment has been challenging to probe directly. In this paper we show that...