2 documents found, page 1 of 1
BIRC3 alterations in chronic and B-cell acute lymphocytic leukemia patients
Alhourani, Eyad; Othman, Moneeb A. K.; Melo, Joana Barbosa; Carreira, Isabel M.; Grygalewicz, Beata; Vujić, Dragana; Zecević, Zeljko; Joksić, GordanaDeletions within chromosome 11q22-23, are considered among the most common chromosomal aberrations in chronic lymphocytic leukemia (CLL), and are associated with a poor outcome. In addition to the ataxia telangiectasia mutated (ATM) gene, the baculoviral IAP repeat-containing 3 (BIRC3) gene is also located in the region. BIRC3 encodes a negative regulator of the non-canonical nuclear factor κ-light-chain-enhanc...
High rates of submicroscopic aberrations in karyotypically normal acute lymphob...
Othman, Moneeb A. K.; Melo, Joana B.; Carreira, Isabel M.; Rincic, Martina; Glaser, Anita; Grygalewicz, Beata; Gruhn, Bernd; Wilhelm, KathleenBackground: Acute lymphoblastic leukemia (ALL) is not a single uniform disease. It consists of several subgroups with different cytogenetic and molecular genetic aberrations, clinical presentations and outcomes. Banding cytogenetics plays a pivotal role in the detection of recurrent chromosomal rearrangements and is the starting point of genetic analysis in ALL, still. Nowadays, molecular (cyto)genetic tools pr...