20 documents found, page 1 of 2
Influence of functional variations in genes of neurotrophins and neurotransmitt...
Fevereiro-Martins, Mariza; Santos, Ana Carolina; Marques-Neves, Carlos; Guimarães, Hercília; Bicho, ManuelRetinal neurodevelopment, vascularization, homeostasis, and stress response are influenced by factors such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), and erythropoietin (EPO). As retinopathy of prematurity (ROP) is a neurovascular retinal disease, this study analyzed the contributions of NGF (rs6330), BDNF (rs7934165), TH (rs10770141), and EPO (rs507392) g...
Genetic modulation of the erythrocyte phenotype associated with retinopathy of ...
Fevereiro-Martins, Mariza; Santos, Ana Carolina; Marques-Neves, Carlos; Guimarães, Hercília; Bicho, ManuelThe development of retinopathy of prematurity (ROP) may be influenced by anemia or a low fetal/adult hemoglobin ratio. We aimed to analyze the association between DNA methyltransferase 3 β (DNMT3B) (rs2424913), methylenetetrahydrofolate reductase (MTHFR) (rs1801133), and lysine-specific histone demethylase 1A (KDM1A) (rs7548692) polymorphisms, erythrocyte parameters during the first week of life, and ROP. In to...
Asymptomatic chronic red eye: a surgical technique case report
Matos, Diogo Bernardo; Guerra, Paulo; José, Patrícia; Ferreira, Rui; Quintas, Ana; Marques-Neves, CarlosIntroduction and importance: Ocular Surface Squamous-cell Neoplasia (OSSN) is an infrequent diagnosis whose clinical suspicion assumes great importance and should not be overlooked. The following case-report aims to describe the diagnosis and treatment of a patient with OSSN whose complaints were mild in comparison to the severity of the disease. The chosen surgical technique was paramount for a disease-free ou...
Retinopathy of prematurity: a review of pathophysiology and signaling pathways
Fevereiro-Martins, Mariza; Marques-Neves, Carlos; Guimarães, Hercília; Bicho, ManuelRetinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading cause of visual impairment and childhood blindness worldwide. The disease is characterized by an early stage of retinal microvascular degeneration, followed by neovascularization that can lead to subsequent retinal detachment and permanent visual loss. Several factors play a key role during the different pathological st...
Complete blood count parameters as biomarkers of retinopathy of prematurity: a ...
Fevereiro-Martins, Mariza; Santos, Ana Carolina; Marques-Neves, Carlos; Guimarães, Hercília; Bicho, Manuel; Afonso, Conceição; Ferreira, JoanaPurpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory d...
Aiming for Single Digit Intraocular Pressure and Drop-Free Surgery in Glaucoma:...
Lopes, Patrícia José Figueiredo; Barão, Rafael; Barata, André; Marques-Neves, Carlos; Silva, José Pedro; Abegão Pinto, LuísINTRODUCTION: Our purpose was to assess patients with single digit intraocular pressure (IOP) values and drop-free in primary trabeculectomy after using mitomycin C (MMC augmented with intracamerular bevacizumab). MÉTODOS: Retrospective, observational and comparative study. Charts from patients who underwent trabeculectomy and with IOP ≤9 mmHg at the last follow-up were included. Sub-analysis of patients screen...
Guidelines for the Management of Center-Involving Diabetic Macular Edema: Treat...
Figueira, João; Henriques, José; Carneiro, Ângela; Marques-Neves, Carlos; Flores, Rita; Castro-Sousa, João Paulo; Meireles, Angelina; Gomes, NunoDiabetic macular edema (DME) is the main cause of visual impairment associated with diabetic retinopathy (DR) and macular laser, during approximately three decades, and was the single treatment option. More recently, intravitreous injections of anti-angiogenics and corticosteroids modified the treatment paradigm associated with significant vision improvements. Nevertheless, not all patients respond satisfactori...
A non-infectious uveitis multidisciplinary clinic in a tertiary referral center...
Leal, Ines; Romão, Vasco C.; Sousa Mano, Sofia; Khmelinskii, Nikita; Campanilho-Marques, Raquel; Ponte, Cristina; Macieira, CarlaNon-infectious uveitis (NIU) is a group of sight-threatening diseases that generates significant burden for the healthcare systems due to its adverse outcomes, irreversible structural complications in the eye with loss of visual function, limited clinical expertise and low-grade evidence for best practice. The usefulness of multidisciplinary care, specifically close collaboration between Rheumatologists and Oph...
Retinal vascular reactivity in type 1 diabetes patients without retinopathy usi...
Sousa, David Cordeiro; Leal, Ines; Moreira, Susana; Vale, Sónia do; Silva-Herdade, Ana S.; Aguiar, Patrício; Dionísio, Patrícia; Pinto, LuisPurpose: We hypothesize that patients with type 1 diabetes (T1D) may have abnormal retinal vascular responses before diabetic retinopathy (DR) is clinically evident. Optical coherence tomography angiography (OCTA) was used to dynamically assess the retinal microvasculature of diabetic patients with no clinically visible retinopathy. Methods: Controlled nonrandomized interventional study. The studied population ...
Tubulointerstitial nephritis and uveitis TINU syndrome : a review
Amaro, David; Carreño, Ester; Steeples, Laura R.; Oliveira Ramos, Filipa; Marques-Neves, Carlos; Leal, InesInflammation of renal interstitium and uveal tissue establishes the two components of tubulointerstitial nephritis and uveitis (TINU) syndrome. Although believed to occur more frequently in young females, a broad spectrum of patients can be affected. Both renal and eye disease can be asymptomatic and may not manifest simultaneously, having independent progressions. Renal disease manifests as acute kidney injury...