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Improving automated model reconstruction across phylogenetically diverse genome...

Faria, José P.; Edirisinghe, Janaka N.; Seaver, Samuel M. D.; Liu, Filipe Alexandre Wang; Weisenhorn, Pamela; Jeffryes, James G.; Gu, Tian; Zhang, Qizh

Date: 2018   |   Origin: RepositóriUM - Universidade do Minho
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Automated pathway curation and improving metabolic model reconstruction based o...

Edirisinghe, Janaka N.; Faria, J.; Liu, Filipe Alexandre Wang; Xavier, Joana Rute Calça; Seaver, Samuel; Weisenhorn, Pamela; Jeffryes, James; Gu, Tian

Metabolic models generated by automated reconstruction pipelines are widely used for high-throughput prediction of microbial phenotypes. However, the generation of accurate in-silico phenotype predictions based solely on genomic data continues to be a challenge as metabolic models often require extensive gapfilling in order to produce biomass. As a result, the true physiological profile of an organism can be al...

Date: 2017   |   Origin: RepositóriUM - Universidade do Minho
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