10 documents found, page 1 of 1
Tenofovir Disoproxil Fumarate: New Chemical Developments and Encouraging in vit...
Clososki,Giuliano C.; Soldi,Rafael A.; Silva,Rodrigo M. da; Guaratini,Thais; Lopes,José N. C.; Pereira,Pâmela R. R.; Lopes,João L. C.; Santos,Thiago dosThe recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led society to live with a serious public health problem. In this sense, repositioning of antiretrovirals has captured the attention of the scientific community. Tenofovir disoproxil fumarate (TDF) is an antiretroviral compound that is used to treat acquired immune deficiency syndrome (AIDS) and hepatitis B. In this short r...
Pharmacokinetic disposition of erythraline in rats after intravenous administra...
Demarque,Daniel P.; Callejon,Daniel R.; Pinto,Larissa G.; Gouvea,Dayana R.; de Moraes,Natália V.; Lopes,João L.C.; Lopes,José N.C.; Lopes,Norberto P.ABSTRACT Erythraline is the major alkaloid produced by Erythrina verna Vell., Fabaceae, a plant used in folk medicine and phytotherapeutic products to treat anxiety and sleep disorders. This study aimed to investigate the pharmacokinetic parameters of erythraline after intravenous administration in rats. For the analysis of erythraline in rat plasma, a method was developed and validated using UHPLC-MS/MS. Pharm...
Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
Silva,Rodrigo M. da; Guaratini,Thais; Jimenez,Paula C.; Fenical,William; Costa-Lotufo,Letícia V.; Vessecchi,Ricardo; Lopes,Norberto P.Seriniquinone is a natural quinone isolated from a rare marine bacterium of the genus Serinicoccus. This secondary metabolite has been shown to have anticancer properties, which has raised attention of the scientific community. In this short report, we present the first investigation of the gas-phase chemistry fragmentation reactions of seriniquinone in electrospray ionization tandem mass spectrometry (ESI-MS/M...
Antioxidant activity and chemical composition of the non polar fraction of Grac...
Guaratini,Thais; Lopes,Norberto P.; Marinho-Soriano,Eliane; Colepicolo,Pio; Pinto,ErnaniGracilaria domingensis (Kützing) Sonder ex Dickie and Gracilaria birdiae (Plastino & Oliveira) (Gracilariales, Rhodophyta) are seaweeds that occur on the Brazilian coast. Based on their economic and pharmaceutical importance, we investigated the antioxidant activity of the methanolic, ethyl acetate and hexane extracts of both species. The hexane extracts display a high antioxidant activity and comparative a...
Aplicação de espectrometria de massas com ionização por elétron na análise de a...
Feitosa,Luís Guilherme Pereira; Guaratini,Thais; Lopes,João Luis Callegari; Lopes,Norberto Peporine; Bizaro,Aline Cavalli; Silva,Denise Brentan daErythrina verna is a medicinal plant used to calm agitation popularly known as mulungu. We purchased the barks of E. verna from a commercial producer and analyzed the alkaloid fraction of the bark by CG-MS and HRESI-MS. Five erythrinian alkaloids were identified: erysotrine, erythratidine, erythratidinone, epimer, and 11-hydroxieritratidinone. Here we report the compound 11-hydroxieritratidinone for the first t...
Differential metabolic and biological profiles of Lychnophora ericoides mart. (...
Gobbo-Neto,Leonardo; Guaratini,Thais; Pessoa,Cláudia; Moraes,Manoel O. de; Costa-Lotufo,Letícia V.; Vieira,Roberto F.; Colepicolo,Pio; Lopes,Norberto P.This paper reports HPLC-DAD-MS/MS and HPLC-ECD characterisation of secondary metabolite profiles of Lychnophora ericoides Mart. leaf extracts from different provenances and their cytotoxic and antioxidant properties. Leaf extracts from populations representing seven different locations were evaluated for antioxidant activity by the DPPH radical scavenging system and activity towards cellular growth in three tum...
Comparison of diode array and electrochemical detection in the C30 reverse phas...
Guaratini,Thais; Cardozo,Karina H. M.; Pinto,Ernani; Colepicolo,PioQualitative and quantitative determination of carotenoids pigments can provide valuable information about the organisms in which this important class of compounds is found. In the HPLC analysis of pigments, diode array (DAD), electrochemical (ED) and other kinds of detector may be used. The aim of this work is to develop an HPLC method using a C30 column to identify and quantify sixteen different pigments from ...
A Fragmentation study of di-acidic mycosporine-like amino acids in electrospray...
Cardozo,Karina H. M.; Vessecchi,Ricardo; Galembeck,Sérgio E.; Guaratini,Thais; Gates,Paul J.; Pinto,Ernani; Lopes,Norberto P.; Colepicolo,PioTwo mycosporine (MAAs), containing an extra acid function, were analyzed by nanospray and electrospray ionization tandem mass spectrometry. In contrast to the previous studies it is demonstrated that no significant characteristic methyl radical loss occurred in positive mode. The fragmentation pathway in negative mode was also proposed in this work, along with theoretical calculations to characterize the site o...
Fotoprotetores derivados de produtos naturais: perspectivas de mercado e intera...
Guaratini,Thais; Callejon,Daniel Roberto; Pires,Dalton Caprari; Lopes,José Norberto Callegari; Lima,Leonardo Mandalho; Giannella Neto,DanielUltraviolet radiation is the major exogenous mediators of skin damage. To prevent such damage, sunscreen products are used. New research aims at both the elucidation of new sunscreen compounds, as well as new assets for supporting and synergistic action. In this article it is presented a systematic data of innovation for sunscreen and a discussion on prospects for partnership between universities and enterprise...
Antioxidantes na manutenção do equilíbrio redox cutâneo: uso e avaliação de sua...
Guaratini,Thais; Medeiros,Marisa H. G.; Colepicolo,PioThe skin is a very complex organ, continuously exposed to physical, chemical and microbiological agents. Enzymes as well as low-molecular weight antioxidants are present in the cutaneous tissue to counterbalance the deleterious effect caused by an oxidative stress and thus maintain homeostasis. Antioxidants such as vitamins C and E, carotenoids, and extracts with these properties have been extensively used for ...