15 documents found, page 1 of 2
In vivo systemic toxicity assessment of an oxidized dextrin‐based hydrogel and ...
Pereira, Isabel; Fraga, Sónia; Maltez, Luís; Requicha, João; Guardão, Luísa; Oliveira, Joana; Prada, Justina; Alves, Helena; Santos, José DomingosThe worldwide incidence of bone disorders is raising, mainly due to aging population. The lack of effective treatments is pushing the development of synthetic bone substitutes (SBSs). Most ceramic-based SBSs commercially available display limited handling properties. Attempting to solve these issues and achieve wider acceptance by the clinicians, granular ceramics have been associated with hydrogels (HGs) to pr...
In vivo systemic toxicity assessment of an oxidized dextrin-based hydrogel and ...
Pereira, Isabel; Fraga, Sónia; Maltez, Luís; Requicha, João; Guardão, Luísa; Oliveira, Joana; Prada, Justina; Alves, Helena; Santos, José DomingosThe worldwide incidence of bone disorders is raising, mainly due to ageing population. The lack of effective treatments is pushing the development of synthetic bone substitutes (SBSs). Most ceramic-based SBSs commercially available display limited handling properties. Attempting to solve these issues and achieve wider acceptance by the clinicians, granular ceramics have been associated with hydrogels to produce...
In vivo biocompatibility and safety asessment of a dextrin-based hydrogel for b...
Pereira, Isabel; Fraga, Sónia; Requicha, João; Guardão, Luísa; Oliveira, Joana; Oliveira, Justina; Alves, Helena; Teixeira, João Paulo; Soares, Raquel[Excerpt] Hydrogels are three dimensional, crosslinked networks of hydrophilic polymers swollen with a large amount of water or biological fluids. They can be combined with granules of ceramic-based synthetic bone substitutes (SBSs) aiming to stabilize them into bone defects and to obtain injectable formulations. Our research group has been characterizing a fully resorbable and injectable dextrin-based hydrogel...
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesi...
Pestana, Diogo; Teixeira, Diana; Meireles, Manuela; Marques, Cláudia; Norberto, Sónia; Sá, Carla; Fernandes, Virgínia; Correia-Sá, Luísa; Faria, AnaEndocrine-disrupting chemicals such as p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), are bioaccumulated in the adipose tissue (AT) and have been implicated in the obesity and diabetes epidemic. Thus, it is hypothesized that p,p'-DDE exposure could aggravate the harm of an obesogenic context. We explored the effects of 12 weeks exposure in male Wistar rats' metabolism and AT biology, assessing a range of met...
Vasculogenesis and Diabetic Erectile Dysfunction: How Relevant Is Glycemic Cont...
Castela, Angela; Gomes, Pedro; Silvestre, Ricardo Jorge Leal; Guardão, Luísa; Leite, Liliana; Chilro, Rui; Rodrigues, Ilda; Vendeira, PedroErectile dysfunction (ED) is a complication of diabetes, condition responsible for causing endothelial dysfunction (EDys) and hampering repair mechanisms. However, scarce information is available linking vasculogenesis mediated by Endothelial Progenitor Cells (EPCs) and diabetes-associated ED. Furthermore, it remains to be elucidated if glycemic control plays a role on EPCs functions, EPCs modulators, and penil...
Excess perigestational folic acid exposure induces metabolic dysfunction in pos...
Keating, Elisa; Correia-Branco, Ana; Araújo, João R,; Meireles, Manuela; Fernandes, Rita; Guardão, Luísa; Guimarães, João T.; Martel, FátimaThe aim of this study was to understand whether high folic acid (HFA) exposure during the perigestational period induces metabolic dysfunction in the offspring, later in life. To do this, female Sprague-Dawley rats (G0) were administered a dose of folic acid (FA) recommended for pregnancy (control, C, 2 mg FA/kg of diet, n=5) or a high dose of FA (HFA, 40 mg FA/kg of diet, n=5). Supplementation began at mating ...
In vitro ACE-inhibitory peptide KGYGGVSLPEW facilitates noradrenaline release f...
Marques, Cláudia; Amorim, Maria Manuela; Pereira, Joana Odila; Guardão, Luísa; Martins, Maria João; Pintado, Manuela Estevez; Moura, DanielThis study aimed to validate the antihypertensive activity of the angiotensin-converting enzyme (ACE)-inhibitor whey protein hydrolysate (WPH) obtained through the action of proteolytic enzymes fromCynara Cardunculus. The antihypertensive activity of WPH fractions containing peptides with molecularweight below 3 kDa (Whey < 3 kDa) and 1 kDa (Whey < 1 kDa) along with the antihypertensive activity ofthree potent ...
Neurokinin-1 receptor, a new modulator of lymphangiogenesis in obese-asthma phe...
Ramalho, Renata; Almeida, Joana; Fernandes, Rúben; Costa, Raquel; Pirraco, Ana; Guardão, Luísa; Delgado, Luís; Moreira, André; Soares, RaquelAims Obesity and asthma are widely prevalent and associated disorders. Recent studies of our group revealed that Substance P (SP) is involved in pathophysiology of obese-asthma phenotype in mice through its selective NK1 receptor (NK1-R). Lymphangiogenesis is impaired in asthma and obesity, and SP activates contractile and inflammatory pathways in lymphatics. Our aim was to study whether NK1-R expression was in...
Can whole blueberries improve metabolic dysfunction?
Norberto, Sónia; Meireles, Manuela; Marques, Cláudia; Guardão, Luísa; Silva, Sara; Pintado, Manuela; Faria, Ana; Calhau, Conceição[Abstract]
Neurogenic inflammation in allergen-challenged obese mice: a missing link in th...
Ramalho, Renata; Almeida, Joana; Beltrão, Marília; Pirraco, Ana; Costa, Raquel; Sokhatska, Oksana; Guardão, Luísa; Palmares, CarmoA number of studies have shown an association between obesity and asthma. Controversy remains on the mechanisms supporting this association. In this study we aimed to assess neurogenic inflammation in a model of diet-induced obesity and allergen-challenged mice. High fat diet-induced (HFD) obese Balb/c mice were sensitized and challenged with ovalbumin (OVA). Glucose, insulin, OVA-specific IgE and substance P (...