2 documents found, page 1 of 1
Size controlled protein nanoemulsions for active targeting of folate receptor p...
Loureiro, Ana Isabel Sá; Nogueira, Eugénia Sofia Costa; Azóia, Nuno G.; Sárria, M. P.; Abreu, Ana S.; Shimanovich, Ulyana; Rollett, AlexandraBovine Serum Albumin (BSA) nanoemulsions were produced by high pressure homogenization with a tri-block copolymer (Poloxamer 407), which presents a central hydrophobic chain of polyoxypropylene (PPO) and two identical lateral hydrophilic chains of polyethylene glycol (PEG). We observed a linear correlation between tri-block copolymer concentration and size - the use of 5 mg/mL of Poloxamer 407 yields nanoemulsi...
Peptide anchor for folate-targeted liposomal delivery
Nogueira, E.; Mangialavori, Irene C.; Loureiro, Ana; Azóia, Nuno G.; Sarria, Marisa P.; Nogueira, Patrícia; Freitas, Jaime; Harmark, JohanSpecific folate receptors are abundantly overexpressed in chronically activated macrophages and in most cancer cells. Directed folate receptor targeting using liposomes is usually achieved using folate linked to a phospholipid or cholesterol anchor. This link is formed using a large spacer like polyethylene glycol. Here, we report an innovative strategy for targeted liposome delivery that uses a hydrophobic fra...