19 documents found, page 1 of 2

International Symposium on Occupational Safety and Hygiene: Proceedings Book of...

International symposium on occupational safety and hygiene: Abstracts book of t...

Outcomes of diabetic patients with acute coronary syndromes treated with aspiri...

The use of aspirin in primary prevention (PP) remains a matter of international debate. In type 2 diabetes mellitus (DM2) patients with high/very high cardiovascular (CV) risk, low dose aspirin may be considered for PP (class IIb, evidence level A) in european guidelines in the absence of hemorrhagic contraindication.

Aberrant hippocampal transmission and behavior in mice with a stargazin mutatio...

Mutations linked to neurodevelopmental disorders, such as intellectual disability (ID), are frequently found in genes that encode for proteins of the excitatory synapse. Transmembrane AMPA receptor regulatory proteins (TARPs) are AMPA receptor auxiliary proteins that regulate crucial aspects of receptor function. Here, we investigate a mutant form of the TARP family member stargazin, described in an ID patient....

Hidrogeologia na envolvente de uma zona termal – Termas de Eirogo (Braga, Portu...

Atualmente, o setor termal encontra-se em forte crescimento. Ao longo do tempo, a sua atividade deixou de ser meramente terapêutica e de bem-estar e passou a ter uma ligação com as energias renováveis. Em Portugal Continental, é conhecida a utilização deste recurso para geotermia, apesar de todas as ocorrências geotérmicas possuírem uma temperatura inferior a 150º C, sendo classificadas de baixa entalpia. Com o...

CRUSADE: Is it still a good score to predict bleeding inacute coronary syndrome?

Introduction: Major bleeding is a serious complication of acute coronary syndrome (ACS) andis associated with a worse prognosis. The CRUSADE bleeding score is used to stratify the risk ofmajor bleeding in ACS.Objective: To assess the predictive ability of the CRUSADE score in a contemporary ACS popu-lation.Methods: In a single-center retrospective study of 2818 patients admitted with ACS, the CRU-SADE score was...

Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer c...

Breast cancer is the most common cancer in women worldwide. Metastatic breast cancer cells are known to display V-H+-ATPase at the plasma membrane, where it is involved in the acquisition of a more metastatic phenotype. Therefore, V-H+-ATPase emerged as a promising candidate for breast cancer therapy, and inhibitors of this pump as potential anticancer drugs. Lactoferrin (Lf) is a natural pro-apoptotic glycopro...

Insights on the molecular mechanisms underlying the anticancer activity of lact...

Lactoferrin (Lf) is an iron-binding protein derived from milk that is present in many tissues and biological fluids. It has been shown that this natural compound exihibits anticancer and anti-metastatic activities as well as cytotoxicity against several cancer cell lines. We have recently found that bovine lactoferrin (bLf) selectively triggers cell death in highly metastatic breast cancer cells through inhibit...

Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer c...

Breast cancer is the most common type of cancer affecting women. Despite the good prognosis when detected early, significant challenges remain in the treatment of metastatic breast cancer. The recruitment of the vacuolar H+-ATPase (V-H+-ATPase) to the plasma membrane, where it mediates the acidification of the tumor microenvironment (TME), is a recognized feature involved in the acquisition of a metastatic phen...

Screening of Lysosomal acid lipase deficiency in patients with severe dyslipide...

Objectives: To determine the prevalence of Lysosomal Acid Lipase (LAL) deficiency in patients with severe dyslipidemia and premature coronary heart disease.