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New methodologies and techniques for biomonitoring pesticide exposure in agricu...

Moreira, Andreia; Guedes, Joana; Silva, Manuela Vieira da; Vieira da Silva, Manuela

Biomonitoring allows for the assessment of internal exposure to various pesticides and metabolites. Following PRISMA guidelines, this systematic review aims to summarise innovative biomonitoring techniques for assessing pesticide exposure in agricultural workers, their advantages and limitations, and their applicability. The search of the Medline/PubMed, ScienceDirect, Scopus, and Web of Science databases ident...


Prevalence of the use of dosimeters for ionizing radiation from fluoroscopy − a...

Videira, Sara; Rodrigues, Matilde; Santos, Joana; Guedes, Joana; Martins, João; Silva, Manuela Vieira da; Vieira da Silva, Manuela; Rodrigues, Matilde

This study aims to assess the prevalence of individual dosimeter use among workers exposed to ionizing radiation during fluoroscopy-guided procedures. Additionally, factors contributing to its use were identified. Studies were identified through searches in five databases on 13 April 2024. Additionally, snowballing techniques were employed. The review followed PRISMA guidelines and the CoCoPop model. A narrativ...


Antimicrobial agents based on metal-ion zeolite materials: a multivariate appro...

Guedes, Joana; Gonçalves, Diogo B.; Rodrigues, Catarina F.; Parpot, Pier; Fonseca, A. M.; Almeida Aguiar, Cristina; Neves, Isabel C.

Bacteria are susceptible to zeolites doped with metal ions. Although the complete mode of action remains unclear, it is widely accepted that metal ions kill bacteria by inducing the production of reactive oxygen species (ROS), which are detrimental to microbial life processes. In this study, two zeolite structures, MFI and LTA, were selected as hosts for the preparation of various metal-ion zeolite materials, w...


Occupational chemical exposure and health status of wildland firefighters at th...

Teixeira, Tatiana; Almeida, Liliana; Dias, Isabel; Baptista, João Santos; Santos, Joana; Vaz, Mário; Guedes, Joana

Wildland firefighting represents a physically and mentally demanding endeavour fraught with various risk factors. The primary aim of this study is to delineate occupational chemical exposure within the firefighting work environment on the firefront and its implications for firefighters’ health status. A systematic literature review was conducted utilising diverse keyword combinations across Scopus, Web of Scien...


Author Correction: Efficient spatially targeted gene editing using a near-infra...

Rebelo, Catarina; Reis, Tiago; Guedes, Joana; Saraiva, Cláudia; Rodrigues, Artur Filipe; Simões, Susana; Bernardino, Liliana; Peça, João


Efficient spatially targeted gene editing using a near-infrared activatable pro...

Rebelo, Catarina; Reis, Tiago; Guedes, Joana; Saraiva, Cláudia; Rodrigues, Artur Filipe; Simões, Susana; Bernardino, Liliana; Peça, João

Spatial control of gene expression is critical to modulate cellular functions and deconstruct the function of individual genes in biological processes. Light-responsive gene-editing formulations have been recently developed; however, they have shown limited applicability in vivo due to poor tissue penetration, limited cellular transfection and the difficulty in evaluating the activity of the edited cells. Here,...



Avaliação longitudinal do impacto causado pela pandemia do Covid-19 no Burnout ...

Alves, Helder; Machado, Idalina; Melo, Sara; Guedes, Joana; Almeida, Sidalina


O uso da Arte na formação dos assistentes sociais em Portugal

Melo, Sara; Machado, Idalina; Guedes, Joana; Mendes, Sandra

Scientific research and professional practice have shown that the different forms of artistic expression (music, theatre, dance, etc.) are particularly effective instruments for social intervention, whether in the prevention, rehabilitation and treatment of people with psychosocial problems, or in their potential to empower and strengthen the social and personal development of individuals in a community. For th...


Glioblastoma hijacks microglial gene expression to support tumor growth

Maas, Sybren L. N.; Abels, Erik R.; Van De Haar, Lieke L.; Zhang, Xuan; Morsett, Liza; Sil, Srinjoy; Guedes, Joana; Sen, Pritha; Prabhakar, Shilpa

Background: Glioblastomas are the most common and lethal primary brain tumors. Microglia, the resident immune cells of the brain, survey their environment and respond to pathogens, toxins, and tumors. Glioblastoma cells communicate with microglia, in part by releasing extracellular vesicles (EVs). Despite the presence of large numbers of microglia in glioblastoma, the tumors continue to grow, and these neuroimm...


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