12 documents found, page 1 of 2
Associative behaviour and antagonism of bovine rumen ciliate (Protista, Cilioph...
D'Agosto, Marta; Guedes, Paulo Marcos da Matta-; Aiming at obtaining the community profile and verifying the occurrence of antagonism and association among ciliates, samples of rumen content were analysed in 100 bovines soon after their death. The animals were killed at the Juiz de Fora Municipal slaughter house (Juiz de Fora, Minas Gerais State, Brazil) between August 1996 and May 1997. Ciliates occurred, respectively, in the following percents and sample...
Myocarditis in different experimental models infected by Trypanosoma cruzi is c...
Caldas, Ivo Santana; Diniz, Lívia de Figueiredo; Guedes, Paulo Marcos da Matta; Nascimento, Álvaro Fernando da Silva do; Galvão, Lúcia Maria da CunhaThis study was designed to verify the relationship between IgG antibodies isotypes and myocarditis inTrypanosoma cruzi infection using mice and dogs infected with different T. cruzi strains. The animals wereinfected with benznidazole-susceptible Berenice-78 and benznidazole-resistant AAS and VL-10 strains.The IgG subtypes were measured in serum samples from dogs (IgG, IgG1, and IgG2) and mice (IgG, IgG1,IgG2a, ...
Hematological alterations during experimental canine infection by Trypanosoma c...
Guedes, Paulo Marcos da Matta; Veloso, Vanja Maria; Mineo, Tiago Wilson Patriarca; Silva, Juliana Santiago; Crepalde, Geovam PereiraPara confirmar que cães Beagle são um bom modelo para doença de Chagas, foram avaliadas as alterações hematológicas durante as fases aguda e crônica em cães Beagle infectados com as cepas Y, Berenice-78 (Be-78) e ABC de Trypanosoma cruzi, correlacionando os sinais clínicos com a curva de parasitemia. Foi demonstrado que a fase aguda da infecção foi marcada por letargia e perda de apetite. Simultaneamente, obser...
Inflammation enhances the risks of stroke and death in chronic chagas disease p...
Guedes, Paulo Marcos da Matta; Andrade, Cléber Mesquita de; Nunes, Daniela Ferreira; Pereira, Nathalie de Sena; Queiroga, Tamyres Bernadete DantasIschemic strokes have been implicated as a cause of death in Chagas disease patients. Inflammation has been recognized as a key component in all ischemic processes, including the intravascular events triggered by vessel interruption, brain damage and repair. In this study, we evaluated the association between inflammatory markers and the death risk (DR) and stroke risk (SR) of patients with different clinical f...
Increased type 1 chemokine expression in experimental Chagas disease correlates...
Guedes, Paulo Marcos da Matta; Veloso, Vanja Maria; Silva, André Talvani Pedrosa da; Diniz, Lívia de Figueiredo; Caldas, Ivo SantanaChemokines and chemokine receptors interaction have presented important role in leukocyte migration to specific immune reaction sites. Recently, it has been reported that chemokine receptors CXC (CXCR3) and CC (CCR5) were preferentially expressed on Th1 cells while CCR3 and CCR4 were preferentially expressed on Th2 cells. This study evaluated the mRNA expression of type 1 and type 2 chemokine and chemokine rece...
Naturally Leishmania infantum-infected dogs display an overall impairment of ch...
Nascimento, Manuela Sales Lima; Albuquerque, Talyta D. R.; Matta, Maria Adelaide do Valle; Caldas, Ivo Santana; Diniz, Lívia de FigueiredoDogs are the primary reservoir for Leishmania parasites. The immune response induced by Leishmania infantum infection in these animals has not been completely elucidated, and few studies have investigated the relationship between the expression levels of chemokines and chemokine receptors and the clinical status of dogs with canine visceral leishmaniasis (CVL). The aim of this study was to correlate the clinica...
Influence of ecto-nucleoside triphosphate diphosphohydrolase activity on Trypan...
Santos, Ramon de Freitas; Pôssa, Marcela Auxiliadora Souza; Bastos, Matheus Silva e; Guedes, Paulo Marcos da Matta; Almeida, Márcia Rogéria deBackground: The protozoan Trypanosoma cruzi is the causative agent of Chagas disease. There are no vaccines or effective treatment, especially in the chronic phase when most patients are diagnosed. There is a clear necessity to develop new drugs and strategies for the control and treatment of Chagas disease. Recent papers have suggested the ecto-nucleotidases (from CD39 family) from pathogenic agents as importa...
IgG isotype profile is correlated with cardiomegaly in Beagle dogs infected wit...
Guedes, Paulo Marcos da Matta; Veloso, Vanja Maria; Gollob, Kenneth John; Afonso, Luís Carlos Crocco; Caldas, Ivo Santana; Vianna, PriscilaA systematic study following infection by various strains of the protozoan parasite, Trypanosoma cruzi, and the simultaneous monitoring of the humoral immune response together with the elicited cellular response, could add greatly to our understanding of differences between strains of this important human pathogen. In that sense, acute and chronic infections with distinct T. cruzi strains (Y, Berenice-78 and AB...
The dog as model for chemotherapy of the Chagas’ disease.
Guedes, Paulo Marcos da Matta; Veloso, Vanja Maria; Tafuri, Washington Luiz; Galvão, Lúcia Maria da Cunha; Carneiro, Cláudia Martins; Lana, Marta deIn the present study, we investigated the role of dogs as experimental models for acute and chronic phases of Chagas’ disease, before and after therapeutic treatments. Dogs were infected with Trypanosoma cruzi strains of different susceptibilities to benznidazole (Bz) and treated with the same therapeutic scheme as used for human chagasic. The treatment with Bz was able to prevent death and induced parasitologi...
Genetic modulation in Be-78 and Y Trypanosoma cruzi strains after long-term inf...
Veloso, Vanja Maria; Guedes, Paulo Marcos da Matta; Lana, Marta de; Martins, Helen Rodrigues; Carneiro, Cláudia MartinsThe genetic profile of Trypanosoma cruzi was evaluated in parasite populations isolated from Beagle dogs experimentally infected with Be-78 and Y strains that present distinct biological and genetic characteristics. Molecular characterization of the isolates obtained 30 days and 2 years after infection was carried out. For typing MLEE, sequence polymorphisms of the mitochondrial cytochrome oxidase subunit II ge...