2 documents found, page 1 of 1
Chemical patterns of proteasome inhibitors: lessons learned from two decades of...
Guedes, R. A.; Aniceto, N.; Andrade, M. A. P.; Salvador, J. A. R.; Guedes, R. C.Drug discovery now faces a new challenge, where the availability of experimental data is no longer the limiting step, and instead, making sense of the data has gained a new level of importance, propelled by the extensive incorporation of cheminformatics and bioinformatics methodologies into the drug discovery and development pipeline. These enable, for example, the inference of structure-activity relationships ...
3-Hydroxypyrrolidine and (3,4)-dihydroxypyrrolidine derivatives: inhibition of ...
Carreiro, E. P.; Louro, P.; Adriano, G; Guedes, R. A.; Vannuchic, N.; Costa, A. R.; Antunes, C. M.; Guedes, R. C.; Burke, A.J.Thirteen pyrrolidine-based iminosugar derivatives have been synthesized and evaluated for inhibition of α-glucosidase from rat intestine. The compounds studied were the non-hydroxy, mono-hydroxy and dihydroxypyrrolidines. All the compounds were N-benzylated apart from one. Four of the compounds had a carbonyl group in the 2,5-position of the pyrrolidine ring. The most promising iminosugar was the trans-3,4-dihy...