81 documents found, page 1 of 9

Unveiling the toxicological risks of synthetic cannabinoid smoking: a GC-MS-bas...

Background: Synthetic cannabinoids (SCs) are a significant class of new psychoactive substances (NPS) commonly consumed via smoking. This process generates pyrolysis byproducts, some of which may exhibit increased toxicity compared to their parent compounds. The structural diversity and rapid emergence of SCs and the use of different herbal products pose challenges in forensic toxicology, necessitating comprehe...

Urinary volatile metabolomic biomarkers for detection of bladder cancer

Background: Early detection of bladder cancer (BC) is necessary for improved outcomes, but current diagnostic methods may lack the necessary sensitivity. Metabolomics, particularly the analysis of urinary volatile organic compounds (VOCs), offers a promising, non-invasive approach to BC detection [1,2]. Objective: The study aimed to investigate potential urinary biomarkers for the detection and staging of ...

Chemical differences between alternative and traditional tobacco products

Background: Electronic cigarettes (E-cigs) and heated tobacco products (HTPs) have gained popularity as alternatives to traditional tobacco products (TTPs), claiming to reduce harm. The carcinogenic properties of chemicals in the smoke of TTPs are widely recognized. However, there is still an incomplete understanding of the different chemicals in E-cigs and HTPs and their toxicity to human cells [1]. Objec...

Metabolic profiling of renal cell carcinoma tissue using gas chromatography met...

Background: Renal cell carcinoma (RCC) is marked by dysregulation of angiogenesis, energy metabolism, and nutrient sensing pathways [1]. This diversity is an obstacle to achieving long-term responses to treatment, notwithstanding progress in targeted and immunotherapeutic drugs. Objective: This study aimed to characterise the metabolic dysregulations that occur in RCC tissue using a metabolomics approach. Metho...

Cisplatin-resistant urothelial bladder cancer cells undergo metabolic reprogram...

Advanced urothelial bladder cancer (UBC) patients are tagged by a dismal prognosis and high mortality rates, mostly due to their poor response to standard-of-care platinum-based therapy. Mediators of chemoresistance are not fully elucidated. This work aimed to study the metabolic profile of advanced UBC, in the context of cisplatin resistance. Three isogenic pairs of parental cell lines (T24, HT1376 and KU1919)...

Essential and non-essential elements, and volatile organic compounds for the di...

The mineral contents and volatile profiles of 23 sweet cherry cultivars were determined. A total of 27 minerals were determined by ICP-MS and flame atomic absorption spectrometry, including 12 essential and 15 non- essential elements. K was the most abundant in all cultivars, while Tl was the one found in the smallest amounts. A total of 66 volatiles were identified using SPME/GC–MS, including 16 aldehydes, 23 ...

Differential cellular effects of sunitinib and pazopanib targeted drugs for met...

Desenvolvimento e validação de método por GC-MS para determinação da Gabapentin...

Urinary volatilomics unveils a candidate biomarker panel for noninvasive detect...

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer usually associated with asymptomatic development and risk of systemic progression. Hence, reliable molecular biomarkers of ccRCC are needed to provide early and minimally invasive detection. In this study, urinary volatilome profiling of patients diagnosed with ccRCC (n = 75), and cancer-free controls (n = 75), was performed to inv...

Integration of metabolomics and lipidomics for prostate cancer tissue fingerpri...