5 documents found, page 1 of 1
Role of Isoprenoid Compounds on Angiogenic Regulation: Opportunities and Challe...
Guerra, Angela R.; Duarte, Iola F.; Duarte, Maria F.Isoprenoids represent one of the largest classes of phytochemicals. The structural diversity of these compounds, as well as their remarkable biological activities, makes them suitable candidates for the development of novel therapeutic agents. Several isoprenoids have demonstrated promising potential in the modulation of angiogenesis processes, and therefore provide an appealing alternative and/or addition to t...
Bioactive Triterpenic Acids: From Agroforestry Biomass Residues to Promising Th...
Domingues, Rui M. A.; Guerra, Angela R.; Duarte, M.; Freire, Carmen S. R.; Neto, Carlos P.; Silva, Carlos M. S.; Silvestre, Arnando J. D.This review aims to provide an overview of the biogenetic origin of triterpenic acids (with particular emphasis on ursolic, oleanolic and betulinic acids), on the analytical extraction and hyphenated methodologies (mainly GC-MS) used on their identification and quantification, followed by an overview of the major sources of these components, indicating their potential large scale production pathways, with espec...
Phenolic composition and antioxidant activity of different morphological parts ...
Ramos, Patricia A. B.; Santos, Sonia A. O.; Guerra, Angela R.; Guerreiro, Olinda; Freire, Carmen S. R.; Rocha, Silvia M.; Duarte, Maria F.The phenolic composition of Cynara cardunculus L. var. altilis (DC) from south of Portugal was determined by analyzing the methanol/water/acetic acid (49.5:49.5:1) extracts of the different morphological parts of the plant, through high temperature-ultra high pressure liquid chromatography tandem mass spectrometry. From the twenty-eight phenolic compounds identified, eriodictyol hexoside was described for the f...
Lipophilic Extracts of Cynara cardunculus L. var. altilis (DC): A Source of Val...
Ramos, Patricia A. B.; Guerra, Angela R.; Guerreiro, Olinda; Freire, Carmen S. R.; Silva, Artur M. S.; Duarte, Maria F.; Silvestre, Armando J. D.Lipophilic extracts of Cynara cardunculus L. var. altilis (DC) from the south of Portugal (Baixo Alentejo) were studied by gas chromatographymass spectrometry. One sesquiterpene lactone, four pentacyclic triterpenes, and four sterols were reported for the first time as cultivated cardoon components, namely, deacylcynaropicrin, beta- and alpha-amyrin, lupenyl and psi-taraxasteryl acetates, stigmasterol, 24-methy...
Valorization of olive mill residues: Antioxidant and breast cancer antiprolifer...
Ramos, Patricia; Santos, Sonia A. O.; Guerra, Angela R.; Guerreiro, Olinda; Felicio, Laura; Jeronimo, Eliana; Silvestre, Armando J. D.Phenolic composition, antioxidant and breast cancer antiproliferative activities of water and methanol/water derived extracts from olive pomace (OP) and dry olive mill residue (DOR), from Portuguese industries, were studied. DOR water (DORW) extracts showed the highest extraction yield; as well as the highest total phenolic content (TPC) and hydroxytyrosol (HT) (similar to 25 mg/g extract). HPLC-ESI-MS analysis...