19 documents found, page 1 of 2

Topical minoxidil-loaded nanotechnology strategies for alopecia

Androgenetic alopecia (AGA) is a multifactorial and age-related condition characterized by substantial hair loss affecting both men and women. Conventional treatments include the use of topical minoxidil (MNX) formulations to stimulate hair growth and restore hair condition. However, those treatments are associated with limited performance and a lack of tolerability and compliance due to the emergence of advers...

Uma Aproximação à Genealogia da Perturbação Borderline da Personalidade

Introdução: A perturbação borderline da personalidade surge na ausência de uma categoria para classificar pessoas que se encontravam entre o diagnóstico de neurose e psicose e tem, desde o seu nascimento, sofrido modificações na sua definição e aplicação clínica. Objectivos: Este artigo tem por objectivo traçar a genealogia da perturbação borderline da personalidade de modo a ensaiar hipóteses para o surgimento...

Comportamento Suicidário nos Internos de Psiquiatria em Portugal: Comparação co...

Introdução: O objectivo deste trabalho foi avaliar a prevalência de ideação suicida e tentativas de suicídio nos médicos internos de psiquiatria de adultos e de psiquiatria da infância e da adolescência em Portugal, e comparar os resultados com a população geral portuguesa e de outros países europeus. Material e Métodos: Enviou-se um questionário estruturado e anónimo, por e-mail, aos 159 internos de psiquiatri...

Personalidade borderline: dos limites do self aos limites do corpo

Introdução: Numa perspectiva psicodinâmica, um dos aspectos essenciais da personalidade borderline é a insuficiente integração do self que se traduz, frequentemente, numa má relação com o corpo e em comportamentos autodestrutivos. Objectivos: Pretendemos abordar o desenvolvimento do self na personalidade borderline, compreender a importância do corpo neste desenvolvimento, assim como o papel dos comportamentos ...

Psychiatry training towards a global future: trainees' perspective in Portugal

Introduction: Psychiatry is influenced by society changes, so it should be permanently updating itself, foreseeing future behaviours and pathologies. This study aims to describe psychiatry trainee’s opinion in Portugal concerning their training and the modifications they would want to witness in the near future. Material and Methods: A structured questionnaire of 26 questions was developed by the Portuguese Ass...

Late-onset Lennox-Gastaut syndrome as a phenotype of 15q11.1q13.3 duplication

The clinical symptoms associated with chromosome 15q duplication syndrome manifest through a heterogeneous group of symptoms characterised by hypotonia, delay in motor skills and language development, cognitive and learning disabilities, autism spectrum disorder and refractory epilepsy. The late development of Lennox-Gastaut syndrome in patients with 15q11q13 duplication is a possibility that physicians should ...

Phase II study on paclitaxel in patients with recurrent, metastatic or locally ...

BACKGROUND: No standard treatment options are available for patients with advanced, recurrent or metastatic vulvar carcinoma not amenable for locoregional treatment. PATIENTS AND METHODS: In this phase II study, patients with advanced vulvar cancer received paclitaxel (Taxol) every 3 weeks for up to 10 cycles. Primary objective was response rate. Secondary objectives were response duration and toxicity. Respons...

Avaliação dos resultados da biópsia do gânglio sentinela no carcinoma da mama

Molecular detection of EGFRvIII-positive cells in the peripheral blood of breas...

The aim of this study is to evaluate epidermal growth factor receptor variant III, EGFRvIII, a cancer specific mutant, as a possible marker for the diagnosis of breast cancer occult systemic disease. EGFRvIII mRNA was identified by an RT-nested PCR with a high sensitivity. In 102 women studied, the mutant was detected in the peripheral blood of 30% of 33 low risk, early stage patients, in 56% of 18 patients sel...

Efeitos secundários da castração com goserelina em mulheres com cancro da mama

In the last few years, ovarian ablation with GnRH agonists has been used as first-line adjuvant therapy in pre and perimenopausal breast cancer. These drugs suppress ovarian function in the hypothalamic-pituitary axis and they have adverse effects in other end-organs. A retrospective study was conducted on 35 premenopausal women, with breast cancer, and treated with goserelin, in order to investigate the effect...