9 documents found, page 1 of 1
The Percentage of [-2]Pro-Prostate-Specific Antigen and the Prostate Health Ind...
Garrido, MM; Marta, JC; Bernardino, RM; Guerra, J; Fernandes, F; Pereira, MH; Ribeiro, R; Holdenrieder, S; Pinheiro, LC; Guimarães, JTContext.— There is a need to avoid the overdiagnosis of prostate cancer (PCa) and to find more specific biomarkers. Objective.— To evaluate the clinical utility of [−2]pro–prostate-specific antigen ([−2]proPSA) derivatives in detecting clinically significant PCa (csPCa) and to compare it with prostate-specific antigen (PSA) and with the percentage of free PSA (%fPSA). Design.— Two hundred thirty-seven men (PSA:...
The Percentage of [−2]Pro–Prostate-Specific Antigen and the Prostate Health Ind...
Garrido, MM; Marta, JC; Bernardino, RM; Guerra, J; Fernandes, F; Pereira, MH; Ribeiro, R; Holdenrieder, S; Pinheiro, LC; Guimarães, JTContext.—: There is a need to avoid the overdiagnosis of prostate cancer (PCa) and to find more specific biomarkers. Objective.—: To evaluate the clinical utility of [-2]pro-prostate-specific antigen ([-2]proPSA) derivatives in detecting clinically significant PCa (csPCa) and to compare it with prostate-specific antigen (PSA) and with the percentage of free PSA (%fPSA). Design.—: Two hundred thirty-seven men (P...
Magnetic Resonance Imaging Target Fusion Biopsy vs. Transrectal Ultrasound-Guid...
Guimarães, T; Gil, M; Medeiros, M; Andrade, V; Guerra, J; Pinheiro, H; Fernandes, F; Pina, J; Lopes Dias, J; Campos Pinheiro, LObjectives: The aim of this study was to com-pare the risk of International Society of Urological Pathology (ISUP) score upgrading between magnetic resonance imaging targeted fusion biopsy (MRI-TB) and tran-srectal ultrasound-guided biopsy (TRUS-B) in the final radical prostatectomy (RP) specimen pathological report. Materials and methods: This retrospective single center study included 51 patients with prostate...
The Impact of Multidisciplinary Team Conferences in Urologic Cancer in a Tertia...
Gil, M; Guerra, J; Andrade, V; Medeiros, M; Guimarães, T; Bernardino, R; Falcão, G; Calais da Silva, F; Campos Pinheiro, LPurpose: Multidisciplinary team (MDT) conferences are currently the standard of care in cancer patients' management. Despite evidence supporting benefits to the majority of malignancies, a paucity of data exists examining the impact in urinary and male genital cancers. This study aims to evaluate the impact of MDT conferences in urologic cancer practice. Methods: Clinical plans discussed in urologic MDT confere...
EHRA Expert Consensus Statement and Practical Guide on Optimal Implantation Tec...
Burri, H; Starck, C; Auricchio, A; Biffi, M; Burri, M; D’Avila, A; Deharo, JC; Glikson, M; Israel, C; Lau, CP; Leclercq, C; Love, C; Nielsen, JWith the global increase in device implantations, there is a growing need to train physicians to implant pacemakers and implantable cardioverter-defibrillators. Although there are international recommendations for device indications and programming, there is no consensus to date regarding implantation technique. This document is founded on a systematic literature search and review, and on consensus from an inte...
Tumor Testing for Somatic and Germline BRCA1/BRCA2 Variants in Ovarian Cancer P...
Peixoto, A; Pinto, P; Guerra, J; Pinheiro, M; Santos, C; Pinto, C; Santos, R; Escudeiro, C; Bartosch, C; Canário, R; Barbosa, A; Gouveia, A; Petiz, ADeleterious variants in the BRCA1/BRCA2 genes and homologous recombination deficiency (HRD) status are considered strong predictors of response to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi). The introduction of PARPi in clinical practice for the treatment of patients with advanced ovarian cancer imposed changes in the molecular diagnosis of BRCA1/BRCA2 variants. BRCA1/BRCA2 tumor testing by next-gen...
Drivers and deterrents of music streaming services purchase intention
Teresa Fernandes; Guerra, JGeneralised access to online content, with no transfer of ownership, revolutionised consumer behaviour. The music industry is a paradigmatic example: physical product sales decreased and even online music stores are increasingly threatened by the rise of on-demand music streaming services (MSS). However, MSS find it difficult to persuade users to opt for the premium version. Therefore, the purpose of this study...
PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated With Strepto...
Fonseca, L; Guerra, J; Neves, N; Machado, A
Impact of Donor and Recipient Cytokine Genotypes on Renal Allograft Outcome
Ligeiro, D; Sancho, MR; Papoila, AL; Barradinhas, AM; Almeida, A; Calão, S; Machado, D; Nolasco, F; Guerra, J; Sampaio, MJ; Trindade, HAllelic differences in gene promoter or codifying regions have been described to affect regulation of gene expression, consequently increasing or decreasing cytokine production and signal transduction responses to a given stimulus. This observation has been reported for interleukin (IL)-10 (-1082 A/G; -819/-592 CT/CA), transforming growth factor (TGF)-beta (codon 10 C/T, codon 25 G/C), tumor necrosis factor (TN...