2 documents found, page 1 of 1
In vitro and in vivo evaluation of quinones from Auxemma oncocalyx Taub. on Lei...
Viana, Sayonara de Melo; Ferreira, Maria Augusta D.; Guerra, Priscila Valera; Viana, Glauce S. Barros; Teixeira, Maria JaniaThe effect of a quinone fraction (QF) isolated from the heartwood of Auxemma oncocalyx Taub. was investigated in vitro and in vivo on Leishmania braziliensis . Although QF (1-10 μ g/mL) showing marked in vitro anti- Leishmania activity (81 to 94%), the oral treatment with the compound did not protect hamsters against progressive L. braziliensis infection. When QF was administered intraperitoneally (20 mg/kg) th...
Efeito protetor de CXCL10 em infecção experimental por Leishmania braziliensis
Guerra, Priscila ValeraLeishmania braziliensis is the more common etiologic agent of the cutaneous leishmaniasis in Brazil. BALB/c mice are more susceptible to L. braziliensis infection, although develop small and not ulcerated lesions. The lesions in BALB/c mice infected by L. braziliensis are accompanied by expression of a broad chemokines spectrum, including CXCL10, which is able to attract and activate NK and Th1 cells with IFN-γ...