4 documents found, page 1 of 1
BK virus-specific T-cell immune reconstitution after allogeneic hematopoietic c...
Ritz, Jerome; Marty, Francisco M.; Soiffer, Robert J.; Antin, Joseph H.; Koreth, John; Ho, Vincent T.; Cutler, Corey S.; Armand, PhilippeClinical disease caused by BK virus reactivation is a frequent complication of allogeneic hematopoietic cell transplantation (HCT). Because of the lack of effective antiviral agents, BK virus-specific T cells are emerging as a potential therapy for BK virus disease, but the immune response to BK virus after allogeneic HCT has not been well characterized. Our study describes reconstitution of BK virus-specific T...
Naive and stem cell memory T cell subset recovery reveals opposing reconstituti...
Soares, Maria Vieira; Azevedo, Rita I.; Ferreira, Ines; Bucar, Sara; Ribeiro, Ana C.; Vieira, Ana I. S.; Pereira, Paulo N G; Ribeiro, Ruy M.The success of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of hematological malignancies remains hampered by life-threatening chronic graft vs. host disease (cGVHD). Although multifactorial in nature, cGVHD has been associated with imbalances between effector and regulatory T cells (Treg). To further elucidate this issue, we performed a prospective analysis of patients underg...
Molecular markers distinguishing T Cell subtypes with TSDR strand-bias methylation
Minskaia, Ekaterina; Saraiva, Bárbara C.; Soares, Maria Vieira; Azevedo, Rita I.; Ribeiro, Ruy M.; Kumar, Saumya; Vieira, Ana I. S.; Lacerda, JoãoHuman regulatory CD4+CD25+FOXP3+ T cells (Treg) play important roles in the maintenance of self-tolerance and immune homeostasis in various disease settings and are also involved in the suppression of effective immune responses. These cells are heterogeneous in phenotype and function, and the ability to reliably distinguish between various FOXP3-expressing subpopulations can affect the development of successful...
Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity...
Gomes, Ana Margarida; Soares, Maria Vieira; Ribeiro, Patrícia; Caldas, Joana; Póvoa, Vanda; Martins, Leila; Melão, Alice; Serra-Caetano, AnaAdult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring a better characterization of the molecular determinants underlying disease progression and resistance to treatment. Here, using a phospho-flow cytometry approach we show that adult diagnostic B-cell acute lymphoblastic leukemia specimens display PI3K/Akt pathway hyperactivation, irrespective of their BCR-ABL status and de...