Encontrados 2 documentos, a visualizar página 1 de 1
Genetic information improves the prediction of major adverse cardiovascular eve...
Mendonça,Maria Isabel; Henriques,Eva; Borges,Sofia; Sousa,Ana Célia; Pereira,Andreia; Santos,Marina; Temtem,Margarida; Freitas,Sónia; Monteiro,JoelAbstract The inclusion of a genetic risk score (GRS) can modify the risk prediction of coronary artery disease (CAD), providing an advantage over the use of traditional models. The predictive value of the genetic information on the recurrence of major adverse cardiovascular events (MACE) remains controversial. A total of 33 genetic variants previously associated with CAD were genotyped in 1587 CAD patients from...
Additional value of a combined genetic risk score to standard cardiovascular st...
Pereira,Andreia; Mendonca,Maria Isabel; Borges,Sofia; Sousa,Ana Célia; Freitas,Sónia; Henriques,Eva; Rodrigues,Mariana; Freitas,Ana Isabel; Guerra,GraçaAbstract The utility of genetic risk scores (GRS) as independent risk predictors remains inconclusive. Here, we evaluate the additive value of a multi-locus GRS to the Framingham risk score (FRS) in coronary artery disease (CAD) risk prediction. A total of 2888 individuals (1566 coronary patients and 1322 controls) were divided into three subgroups according to FRS. Multiplicative GRS was determined for 32 gene...