23 documents found, page 1 of 3
Recommendations by the Scientific Department of Neuroimmunology of the Brazilia...
Becker,Jefferson; Ferreira,Lis Campos; Damasceno,Alfredo; Bichuetti,Denis Bernardi; Christo,Paulo Pereira; Callegaro,DagobertoABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acut...
Polymorphisms in the CIITA −168A/G (rs3087456) and CIITA +1614G/C (rs4774) may ...
Pereira,Valéria Coelho Santa Rita; Fontes-Dantas,Fabrícia Lima; Paradela,Eduardo Ribeiro; Malfetano,Fabíola RachidABSTRACT It is currently unknown how genetic factors may influence the clinical course of multiple sclerosis (MS). Objective: We examined the impact of CIITA polymorphisms −168A/G (rs3087456) and +1614G/C (rs4774) on the risk of disability progression, severity and on responses to first-line immunomodulator treatments. Methods: Genomic DNA was extracted from blood samples. We used ABI3730xl and GeneMapper v.4.0...
No correlation was observed between vitamin D levels and disability of patients...
Fragoso,Yara Dadalti; Adoni,Tarso; Alves-Leon,Soniza Vieira; Apostolos-Pereira,Samira L.; Arruda,Walter Oleschko; Brooks,Joseph B. BidinABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The...
Clinical characteristics of patients with cerebellar ataxia associated with ant...
Aguiar,Tiago Silva; Fragoso,Andrea; Albuquerque,Carolina Rouanet de; Teixeira,Patrícia de Fátima; Souza,Marcus Vinícius Leitão de; Zajdenverg,LenitaABSTRACT The enzyme glutamic acid decarboxylase (GAD), present in GABAergic neurons and in pancreatic beta cells, catalyzes the conversion of gamma-aminobutyric acid (GABA). The cerebellum is highly susceptible to immune-mediated mechanisms, with the potentially treatable autoimmune cerebellar ataxia associated with the GAD antibody (CA-GAD-ab) being a rare, albeit increasingly detected condition. Few cases of ...
Safety of switching from natalizumab straight into fingolimod in a group of JCV...
Fragoso,Yara Dadalti; Alves-Leon,Soniza Vieira; Becker,Jefferson; Brooks,Joseph Bruno Bidin; Correa,Eber Castro; Damasceno,Alfredo; Gama,Paulo Diniz daABSTRACT Objective To assess safety of the switch between natalizumab and fingolimod without a washout period. Methods Prospective data on 25 JCV positive patients who underwent this medication switch were collected and analyzed. Results After a median period of nine months from the medication switch, there were no safety issues to report. The patients had good disease control and no adverse events were reporte...
Natalizumab adverse events are rare in patients with multiple sclerosis
Fragoso,Yára Dadalti; Alves-Leon,Soniza Vieira; Arruda,Walter Oleschko; Carvalho,Margarete de Jesus; Comini-Frota,Elizabeth Regina; Corrêa,Éber CastroObjective To assess the prevalence and the profile of adverse events (AE) of natalizumab in patients with multiple sclerosis (MS). Methods Data collection from neurologists attending to patients with MS at specialized units in Brazil. Results Data from 103 patients attending the infusion centers of 16 MS units in 9 Brazilian states were included in the study. The total number of infusions was 1,042. Seventy-nin...
Multiple sclerosis in South America: month of birth in different latitudes does...
Fragoso,Yara Dadalti; Adoni,Tarso; Almeida,Sandra Maria Garcia de; Alves-Leon,Soniza Vieira; Arruda,Walter Oleschko; Barbagelata-Aguero,FiorellaObjective To assess whether the month of birth in different latitudes of South America might influence the presence or severity of multiple sclerosis (MS) later in life. Methods Neurologists in four South American countries working at MS units collected data on their patients' month of birth, gender, age, and disease progression. Results Analysis of data from 1207 MS patients and 1207 control subjects did not s...
Diffusion tensor magnetic resonance imaging may show abnormalities in the norma...
Miraldi,Fernanda; Lopes,Fernanda Cristina Rueda; Costa,Joao Victor Altamiro; Alves-Leon,Soniza Vieira; Gasparetto,Emerson LeandroObjective This study aims to evaluate “in vivo” the integrity of the normal-appearing spinal cord (NASC) in patients with multiple sclerosis (MS) compared to controls, using diffusion tensor MR imaging. Methods We studied 32 patients with MS and 17 without any neurologic disorder. Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD) were calculated within regions...
Syncope in patients with drug-resistant epilepsy without apparent cardiovascula...
Alves-Leon,Soniza Vieira; Pinto,Moises Pereira; Andraus,Maria Emilia Cosenza; Pereira,Valeria Coelho Santa Rita; Meira,Isabella D'AndreaEpilepsy and syncope are clinical conditions with high prevalence rates in the general population, and the differential diagnosis between them is difficult. Objective To assess the frequency of syncope in patients diagnosed with drug-resistant epilepsy (DRE) without apparent heart disease, to investigate the relationship between clinical and electroencephalographic (EEG) changes, and to verify the role of the ...
Periodic EEG patterns: importance of their recognition and clinical significance
Andraus,Maria Emilia Cosenza; Andraus,Cesar Fantezia; Alves-Leon,Soniza VieiraPeriodic electroencephalographic (EEG) patterns consist of discharges usually epileptiform in appearance, which occur at regular intervals, in critical patients. They are commonly classified as periodic lateralized epileptiform discharges (PLEDs), bilateral independent PLEDs or BIPLEDs, generalized epileptiform discharges (GPEDs) and triphasic waves. Stimulus-induced rhythmic, periodic or ictal discharges (SIRP...