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Incidental versus symptomatic nonfunctioning pituitary adenomas: Are they diffe...

Guerreiro, V; Mendonça, F; Ferreira, HU; Freitas, P; Pereira, J; Bernardes, I; Pinheiro, J; Guimarães, T; Carvalho, D

Background Nonfunctioning pituitary adenomas (NFPAs) constitute one of the most common tumours in the sellar region and are often discovered only when associated with compressive symptoms. With the frequent use of brain imaging, there has been an increase in the prevalence of incidentally discovered NFPAs.Aim We aim to determine the prevalence of incidental diagnosis with NPAs observed over a decade and compare...


Oral glucose tolerance testing at 1 h and 2 h: relationship with glucose and ca...

Guerreiro, V; Maia, I; Neves, JS; Salazar, D; Ferreira, MJ; Mendonça, F; Silva, MM; Borges-Canha, M; Viana, S; Costa, C; Pedro, J; Varela, A; Lau, E

Background: One hour plasma glucose concentration (1hPG) during an oral glucose tolerance test (OGTT) may be an alternative to 2-h plasma glucose concentration (2hPG) in the identification of individuals at increased risk of hyperglycaemia, although its role is not fully understood. Aim: We aim to investigate the relationship of these measures with other glucose parameters, as well as their relationship with ca...


Mixed medullary-papillary thyroid carcinoma with mixed lymph node metastases: A...

Guerreiro, V; Costa, C; Oliveira, J; Santos, AP; Farinha, M; Jácome, M; Freitas, P; Carvalho, D; Torres, I

Mixed medullary-follicular-derived carcinoma is a very rare event. It is extremely important to make the correct diagnosis, due to prognostic and treatment implications. A genetic study of these patients is advisable to exclude the presence of MEN 2.


Adequate magnesium level as an associated factor of pre-diabetes and diabetes m...

Guerreiro, V; Maia, I; Neves, JS; Salazar, D; Ferreira, MJ; Mendonça, F; Silva, MM; Viana, S; Costa, C; Pedro, J; Varela, A; Lau, E; Freitas, P

Bariatric surgery (BS) can lead to remission of type 2 diabetes mellitus (T2DM), however, the evidence on the influence of preoperative serum magnesium levels on this reversal is scarce. To study the influence of preoperative serum magnesium levels on the pre-T2DM and T2DM remission one year after BS. Retrospective study carried out among 1656 patients with obesity who underwent BS in the Centro Hospitalar Univ...


Secondary Hyperparathyroidism Among Bariatric Patients: Unraveling the Prevalen...

Mendonça, FM; Neves, JS; Silva, MM; Borges Canha, M; Costa, C; Cabral, PM; Guerreiro, V; Lourenço, R; Meira, P; Correia, Flora; Salazar, D; Pedro, J

Introduction Bariatric surgery (BS) is the most effective therapeutic approach to obesity. It is associated with great gastrointestinal anatomic changes, predisposing the patients to altered nutrient absorption that impacts phosphocalcium metabolism. This study aimed to clarify the prevalence of secondary hyperparathyroidism (SHPT) and its predictors in patients submitted to BS. Methods Retrospective study of 1...


The impact of vitamin d in non-alcoholic fatty liver disease: A cross-sectional...

Borges-Canha, M; Neves, JS; Mendonça, F; Silva, MM; Costa, C; Cabral, PM; Guerreiro, V; Lourenço, R; Meira, P; Salazar, D; Ferreira, MJ; Pedro, J

Purpose: We aimed to evaluate the association between vitamin D status and hepatic function parameters and scores: Fatty Liver Index (FLI, predictor of hepatic steatosis) and BARD (BMI, AST/ALT ratio and DM, predictor of hepatic fibrosis) in patients with morbid obesity. Patients and Methods: Cross-sectional study including patients with morbid obesity followed in our centre between January 2010 and July 2018. ...


Beta Cell Function as a Baseline Predictor of Weight Loss After Bariatric Surgery

Borges-Canha, M; Neves, JS; Mendonça, F; Silva, MM; Costa, C; M Cabral, P; Guerreiro, V; Lourenço, R; Meira, P; Salazar, D; Ferreira, MJ; Pedro, J

Background: Obesity is a multifactorial disease, which is strongly associated to other metabolic disorders. Bariatric surgery is the most effective treatment of morbid obesity. The role of beta cell function in weight loss after bariatric surgery is uncertain. Aim: To evaluate the association between beta cell function and percentage of total body weight loss (TBWL%) 1, 2, 3, and 4 years after bariatric surgery...


Impact of Bariatric Surgery on Long-term Cardiovascular Risk: Comparative Effec...

Oliveira, SC; Neves, JS; Souteiro, P; Pedro, J; Magalhães, D; Guerreiro, V; Bettencourt-Silva, R; Costa, MM; Varela, A; Barroso, I; Freitas, P

Introduction: Several reports highlight bariatric surgery as an efficient and long-lasting strategy for weight loss. Herein, we aimed to evaluate the impact of bariatric surgery on 10-year cardiovascular disease (CVD) risk and to compare the effectiveness of different surgical procedures, employing the Framingham Risk Score (FRS). Methods: Retrospective longitudinal observational study of patients undergoing ba...


Bariatric Surgery Impact on Cardiovascular Risk Factors: Is Age a Factor to Con...

Mendonça, F; Silva, MM; Salazar, D; Correia, Flora; Pedro, J; Guerreiro, V; Viana, S; Neves, JS; Belo, S; Varela, A; Freitas, P; Carvalho, Davide

Introduction: Despite the abundance of data addressing the influence of patient's age on surgery-related complications, its impact on cardiometabolic outcomes following bariatric surgery has been overlooked. Methods: Retrospective unicentric study of 1,728 obese patients who underwent bariatric surgery between January 2010 and June 2015. Patients were divided in 3 age groups, according to their age at surgery: ...


Thyroid Function and the Risk of Non-Alcoholic Fatty Liver Disease in Morbid Ob...

Borges-Canha, M; Neves, JS; Mendonça, F; Silva, MM; Costa, C; Cabral, PM; Guerreiro, V; Lourenço, R; Meira, P; Salazar, D; Ferreira, MJ; Pedro, J

Background: An association between hypothyroidism and the risk of Non-alcoholic Fatty Liver Disease (NAFLD) has been suggested. This association remains to be elucidated in patients with morbid obesity. Aim: To evaluate the association between thyroid function and parameters of liver function and hepatic scores in patients with morbid obesity. Methods: Patients with morbid obesity followed in our center between...


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