22 documents found, page 1 of 3
Modification in body weight associated with antiepileptic drugs
Gaspari,Camilla N. De; Guerreiro,Carlos A.M.Antiepileptic drugs (AED) may cause body weight changes. OBJECTIVE: To evaluate the dietary habits and body weight associated with AED in epileptic patients. METHOD: Sixty-six patients were subjected to two interviews, and had their weight and body mass index calculated and compared at both times, interval between six to eight months. RESULTS: It was observed that 59.1% showed weight gain. The patients who had ...
Accident risk in patients with epilepsy
Souza,Karla Teixeira; Guerreiro,Marilisa M.; Guerreiro,Carlos A.M.OBJECTIVE: To compare the risk of accidents in patients with uncontrolled seizures, in seizure-free patients, and in patients with chronic headache. METHOD: This was a prospective longitudinal case-controlled study with interviews. A semi-structured questionnaire was used in the epilepsy and headache outpatient clinics of the Hospital das Clínicas of UNICAMP. RESULTS: Group I was composed of 48 patients with un...
Guidelines for drug treatment of epilepsy: a critical review
Guerreiro,Carlos A.M.This article critically reviews the role of evidence-based medicine and its guidelines, from their logistic preparation to their interpretation. The strengths and weaknesses of the methodological points are presented, as well the reasons for the extreme popularity of the guidelines in developed countries. The review discusses the main foundations of the most cited guidelines and some recent large studies. Some ...
The clinical spectrum of malformations of cortical development
Montenegro,Maria Augusta; Cendes,Fernando; Lopes-Cendes,Iscia; Guerreiro,Carlos A.M.; Li,Li M.; Guerreiro,Marilisa M.BACKGROUND: Malformations of cortical development (MCD) usually manifest in childhood with epilepsy, developmental delay and focal neurological abnormalities. OBJECTIVE: To evaluate the presentation and severity of epilepsy in the different types of MCD. METHOD: We evaluated the first 100 consecutive patients with a neuroimaging diagnosis of MCD. They were identified among all the high resolution magnetic reson...
Demonstration project on epilepsy in Brazil: situation assessment
Li,Li M.; Fernandes,Paula T.; Noronha,Ana L.A.; Marques,Lucia H.N.; Borges,Moacir A.; Cendes,Fernando; Guerreiro,Carlos A.M.; Zanetta,Dirce M.T.PURPOSE: To provide a situation assessment of services for people with epilepsy in the context of primary health care, as part of the Demonstration Project on Epilepsy in Brazil, part of the WHO/ILAE/IBE Global Campaign 'Epilepsy out of the shadows'. METHODS: We performed a door-to-door epidemiological survey in three areas to assess the prevalence of epilepsy and its treatment gap. We surveyed a sample of 598 ...
Demonstration project on epilepsy in Brazil: outcome assessment
Li,Li M.; Fernandes,Paula T.; Noronha,Ana L.A.; Marques,Lucia H.N.; Borges,Moacir A.; Borges,Karina; Cendes,Fernando; Guerreiro,Carlos A.M.PURPOSE: To assess the outcome of patients with epilepsy treated at primary care health units under the framework of the demonstration project on epilepsy in Brazil, part of the WHO/ILAE/IBE Global Campaign Against Epilepsy. METHOD: We assessed the outcome of patients treated at four primary health units. The staff of the health units underwent information training in epilepsy. The outcome assessment was based ...
Pharmacovigilance in epileptic patients using antiepileptic drugs
Mei,Paulo Afonso; Montenegro,Maria Augusta; Guerreiro,Marilisa M.; Guerreiro,Carlos A.M.OBJECTIVE: To investigate the occurrence of adverse effects of antiepileptic drugs (AED) in chronic epileptic patients in mono or polytherapy. METHOD: We evaluated consecutive patients that met the following inclusion criteria: age of 18 years or older, diagnosis of epilepsy for at least one year, stable dose of AED for at least three months. Patients were asked if they had any adverse event related to the AED....
Interictal electroencephalographic findings in children and adults with tempora...
Franzon,Renata C.; Montenegro,Maria Augusta; Yasuda,Clarissa Lin; Guimarães,Catarina A.; Guerreiro,Carlos A.M.; Cendes,Fernando; Valente,Kette D.OBJECTIVE: To characterize clinical and interictal electroencephalographic aspects of children and adults with temporal lobe epilepsy (TLE) due to tumoral lesions. METHOD: We performed a retrospective analysis of the clinical and interictal electroencephalographic aspects of 16 children (64 exams) and 12 adults (78 exams) with lesions in the temporal lobe. RESULTS: The most frequent etiologies were gangliogliom...
Effectiveness of clobazam as add-on therapy in children with refractory focal e...
Silveira,Mariana Ribeiro Marcondes da; Montenegro,Maria Augusta; Franzon,Renata Cristina; Guerreiro,Carlos A.M.; Guerreiro,Marilisa M.The objective of this study was to evaluate the safety and efficacy of clobazam in children with refractory focal epilepsy. We investigated 100 consecutive patients concerning etiology of epilepsy, previously used antiepileptic drugs, seizure frequency and adverse events. Clobazam was introduced as add-on therapy in patients with previous failure of at least two monotherapies. Mean age was eight years-old and 3...
Menstrual cycle worsening of epileptic seizures in women with symptomatic focal...
Bazán,Ana Carolina Belini; Montenegro,Maria Augusta; Cendes,Fernando; Min,Li Li; Guerreiro,Carlos A.M.INTRODUCTION: Hormonal fluctuation is responsible for worsening of epileptic seizures during the menstrual cycle. OBJETIVE: To identify irregularities in the menstrual cycles of women with mesial temporal lobe epilepsy (MTLE) and extratemporal focal epilepsy (ETFE) and correlate the frequency of seizures during the menstrual cycles. METHOD: We evaluated prospectively women in the menacme with MTLE and ETFE. Cal...