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Delivery system for mefenamic acid based on the nanocarrier layered double hydr...
Cunha, Vanessa R. R.; Guilherme, Viviane A.; Paula, Eneida de; Araujo, Daniele R. de; Silva, Renan O.; Medeiros, Jand V. R.; Leite, José R. S. A.Purpose The anionic form of the drug mefenamic acid intercalated into the nanocarrier layered double hydroxide (LDH-Mef) was evaluated by anti-inflammatory and antinociceptive assays. Methods The LDH-Mef material was characterized by a set of physicochemical techniques, which was supported by Density Functional Theory calculations. The pharmacological effects of LDH-Mef (40 wt% of drug) were evaluated by hemoly...
Date: 2017
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Origin: Oasisbr