Encontrados 16 documentos, a visualizar página 1 de 2
Plant-based pharmacological alternatives in the seizure treatment: A patent review
Pina, Lícia Tairiny Santos; Guimarães, Adriana Gibara; Sampaio, Laeza Alves; Guimarães, Juliana Oliveira; Rabelo, Thallita Kelly; Savi, Flávia MedeirosEpilepsy, a neurologic condition associated with recurring seizures, affects around 70 million people worldwide and it is responsible for health costs. The current drug therapies used for treating epilepsy have low efficacy and many adverse side effects. In addition, drug resistance can also be found. The association of these factors considerably compromises the patient's pharmacotherapy care. Therefore, natura...
Impact of detention structure on the occurrence of SARS-CoV-2 infection in youn...
Borges, Lysandro Pinto; Guimarães, Adriana Gibara; Souza, Daniela Raguer Valadão de; Martins, Aline Fagundes; Rezende Neto, José Melquiades deConsidering that COVID-19 is a respiratory disease transmitted by contact and places of incarceration are an environment that imposes additional risks for viral spread, this study sought to identify cases of SARS-CoV-2 infection in socio-educational units. We evaluated the seroprevalence of IgM and IgG for SARS-CoV-2 in workers and adolescents confined in five socio-educational units. Adolescents and workers te...
COVID-19 mortality profile during the first 15 months of the pandemic
Borges, Lysandro Pinto; Silva, Hérica Santos da; Silva, José Rodrigo Santos; Guimarães, Adriana GibaraSince the beginning of the COVID-19 pandemic, the mortality profile and associated risk factors have been widely traced in different parts of the world. So, we analyse the occurrence of deaths by bulletin of the State Health Department of Sergipe, Brazil published on June 9, 2021. Data were analyzed descriptively and inferential using R software. Sergipe registered 5,295 deaths due to the new coronavirus during...
Efeito do carvacrol e do seu complexo de inclusão com β-ciclodextrina sobre a n...
Guimarães, Adriana GibaraThroughout the history of the development of treatments proposed for pain, medicinal plants and their secondary metabolites have played a key role. However, even more effective therapeutic options for the treatment of painful conditions are necessary. In this sense, the present study aimed to evaluate the effect of the inclusion complex of β-cyclodextrin (β-CD) containing carvacrol, a phenolic monoterpene prese...
Carvacrol, (−)-borneol and citral reduce convulsant activity in rodents
Quintans-Júnior, Lucindo José; Guimarães, Adriana Gibara; Araújo, Bruno Eduardo Silva de; Cavalcanti, Sócrates Cabral de HolandaCarvacrol, a monoterpenic phenol present in essential oils of the Labiatae family, has been used through the ages as a source of flavor in food and for medicinal purposes. Borneol is a monoterpene found in several species of Artemisia and Dipterocarpaceae, used for anxiety, pain and anesthesia in traditional Chinese. Citral, a mixture of two geometrical isomers (neral and geranial), is one of the most important...
Morinda citrifolia linn leaf extract possesses antioxidant activities and reduc...
Serafini, Mairim Russo; Santos, Rodrigo Correia; Guimarães, Adriana Gibara; Santos, João Paulo Almeida dos; Santos, Alan Diego da ConceiçãoThis is a copy of an article published in the Journal of Medicinal Food© 2011 - copyright Mary Ann Liebert, Inc.; Journal of Medicinal Food is available online at: http://online.liebertpub.com; Herbal drugs have been used since ancient times to treat a wide range of diseases. Morinda citrifolia Linn (popularly known as ‘‘Noni’’) has been used in folk medicine by Polynesians for over 2,000 years. It is reported ...
Anti-inflammatory and redox-protective activities of citronellal
Melo, Mônica Santos de; Guimarães, Adriana Gibara; Santana, Michele Fraga de; Barreto, Rosana de Souza Siqueira; Lima, Amanda do Carmo Bion deThe anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and arachidonic acid-induced rat hind paw edema was significantly inhibited (p < 0.05) by i.p. admi...
Citral reduces nociceptive and inflammatory response in rodents
Quintans-Júnior, Lucindo José; Guimarães, Adriana Gibara; Santana, Marília Trindade de; Araújo, Bruno Eduardo Silva de; Moreira, Flávia VianaCitral (CIT), which contains the chiral enantiomers, neral (cis) and geranial (trans), is the majority monoterpene from Lippia alba and Cymbopogon citratus. The present study aimed to evaluate CIT for antinociceptive and anti-inflammatory activities in rodents. Antinociceptive and anti-inflammatory effects were studied by measuring nociception through acetic acid and formalin tests, while inflammation was verif...
Phytochemical screening, antinociceptive and anti-inflammatory effects of the e...
Andrade, Gilmara S.; Guimarães, Adriana Gibara; Santana, Marília Trindade de; Siqueira, Rosana de Souza; Passos, Luiz OliveiraThis report aimed to investigate the chemical composition and possible antinociceptive and anti-inflammatory effects of the essential oil from fresh leaves of Myrcia pubiflora DC., Myrtaceae (EOMP), through different experimental tests. The essential oil of M. pubiflora (EOMP) was obtained by hydrodistillation, analyzed by GC-MS, and tested at doses of 25, 50, and 100 mg/kg (i.p.) in three different tests of no...
p-Cymene reduces orofacial nociceptive response in mice
Santana, Michele Fraga de; Quintans-Júnior, Lucindo José; Cavalcanti, Sócrates Cabral de Holanda; Oliveira, Makson Gleydson Brito deThis study investigated the possible antinociceptive effect of p-cymene in different tests of orofacial nociception. The animals (mice) were pretreated (i.p.) with p-cymene (25, 50, 100 mg/kg), morphine (5 mg/kg), or vehicle (0.2% Tween 80+saline), and were then subsequently administered, subcutaneously into their upper lip: formalin, capsaicin, and glutamate. The nociceptive behavior response was characterized...