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Transmural remission improves clinical outcomes up to 5 years in Crohn's disease

Fernandes, Samuel; Serrazina, Juliana; Botto, Inês Ayala; Leal, Tiago; Guimarães, Andreia; Garcia, Joana Lemos; Rosa, Isadora; Prata, Rita

Introduction: Evidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long-term. Methods: Multicenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colon...


Transmural remission improves clinical outcomes up to 5 years in Crohn's disease

Fernandes, Samuel Raimundo; Serrazina, Juliana; Botto, Inês Ayala; Leal, Tiago; Guimarães, Andreia; Garcia, Joana Lemos; Rosa, Isadora; Prata, Rita

IntroductionEvidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long-term. MethodsMulticenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colonosco...


Parkinson’s Disease and Fabry Disease: Clinical, Biochemical and Neuroimaging A...

Gago, Miguel Fernandes; Azevedo, Olga; Guimarães, Andreia; Teresa Vide, Ana; Lamas, Nuno J.; Oliveira, Tiago Gil; Gaspar, Paulo; Bicho, Estela

Background: Sporadic Parkinson's disease (PD) patients have lower α-galactosidase A (α-GAL A) enzymatic activity and Fabry disease (FD) patients potentially carry an increased risk of PD. Objective: Determination of PD prevalence in FD and clinical, biochemical and vascular neuroimaging description of FD pedigrees with concomitant PD. Methods: Clinical screening for PD in 229 FD patients belonging to 31 familie...


Parkinson’s Disease and Fabry Disease: Clinical, Biochemical and Neuroimaging A...

Gago, Miguel Fernandes; Azevedo, Olga; Guimarães, Andreia; Teresa Vide, Ana; Lamas, Nuno J.; Oliveira, Tiago Gil; Gaspar, Paulo; Bicho, Estela

Background: Sporadic Parkinson's disease (PD) patients have lower α-galactosidase A (α-GAL A) enzymatic activity and Fabry disease (FD) patients potentially carry an increased risk of PD. Objective: Determination of PD prevalence in FD and clinical, biochemical and vascular neuroimaging description of FD pedigrees with concomitant PD. Methods: Clinical screening for PD in 229 FD patients belonging to 31 familie...


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