Mammalian odorant-binding proteins (OBPs) represent a fascinating class of small, soluble proteins that transport odors from the air to the olfactory receptors, through the nasal mucus. OBPs can accommodate diverse odorant molecules through their flexible binding pockets, undergoing conformational changes upon ligand binding. Acknowledge of release mechanism could be very useful to provide a controllable releas...
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Polyoxyethanyl--tocopheryl sebacate (PTS) is an amphiphilic compound with self-emulsifying properties known to form micelles. In this work, we report the production of PTS micelles for the encapsulation and delivery of a hydrophobic derivative of methotrexate, MTX di-ethylated (MTX-OEt). We optimized the micelles production by testing two different techniques: auxiliary solvent and sonication. Small and homogen...
The Internet of Things (IoT) is experiencing rapid growth and being adopted across multiple domains. For example, in industry it supports the connectivity needed to integrate smart machines, components and products in the ongoing Industry 4.0 trend. However, there is a myriad of communication technologies that complicate the needed integration, requiring gateways to connect to the Internet. Conversely, using IE...
The Internet of Things (IoT) is experiencing rapid growth and being adopted across multiple domains. For example, in industry it supports the connectivity needed to integrate smart machines, components and products in the ongoing Industry 4.0 trend. However, there is a myriad of communication technologies that complicate the needed integration, requiring gateways to connect to the Internet. Conversely, using IE...
Machine-to-Machine (M2M) communications are a key enabler of Internet of Things (IoT) applications. One domain with growing interest in M2M/IoT is e-health, either for self-monitoring, home monitoring, or hospital systems. However, current sensing devices in this domain rely on short-range communication protocols that require a gateway (GW) for Internet connection. Smartphones have been proposed as GWs in mobil...
Tese de Doutoramento em Ciências da Educação.; No contexto atual, a escola enquanto organização suscita novas interpelações na tentativa de adequar a educação às exigências das transformações sociais e económicas. Por forma a dar uma resposta eficaz à sua missão, surge o Projeto Educativo como o documento que consagra a orientação educativa do agrupamento de escolas ou de escolas não agrupadas, desenhado para u...