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Polyoxyethanyl--tocopheryl sebacate (PTS) is an amphiphilic compound with self-emulsifying properties known to form micelles. In this work, we report the production of PTS micelles for the encapsulation and delivery of a hydrophobic derivative of methotrexate, MTX di-ethylated (MTX-OEt). We optimized the micelles production by testing two different techniques: auxiliary solvent and sonication. Small and homogen...
Machine-to-Machine (M2M) communications are a key enabler of Internet of Things (IoT) applications. One domain with growing interest in M2M/IoT is e-health, either for self-monitoring, home monitoring, or hospital systems. However, current sensing devices in this domain rely on short-range communication protocols that require a gateway (GW) for Internet connection. Smartphones have been proposed as GWs in mobil...
The Internet of Things (IoT) is experiencing rapid growth and being adopted across multiple domains. For example, in industry it supports the connectivity needed to integrate smart machines, components and products in the ongoing Industry 4.0 trend. However, there is a myriad of communication technologies that complicate the needed integration, requiring gateways to connect to the Internet. Conversely, using IE...
The Internet of Things (IoT) is experiencing rapid growth and being adopted across multiple domains. For example, in industry it supports the connectivity needed to integrate smart machines, components and products in the ongoing Industry 4.0 trend. However, there is a myriad of communication technologies that complicate the needed integration, requiring gateways to connect to the Internet. Conversely, using IE...
Tese de Doutoramento em Ciências da Educação.; No contexto atual, a escola enquanto organização suscita novas interpelações na tentativa de adequar a educação às exigências das transformações sociais e económicas. Por forma a dar uma resposta eficaz à sua missão, surge o Projeto Educativo como o documento que consagra a orientação educativa do agrupamento de escolas ou de escolas não agrupadas, desenhado para u...
The accumulation of lead in several bones of Wistar rats with time was determined and compared for the different types of bones. Two groups were studied: a control group (n = 20), not exposed to lead and a contaminated group (n = 30), exposed to lead from birth, first indirectly through mother's milk, and then directly through a diet containing lead acetate in drinking water (0.2%). Rats age ranged from 1 to 11...