17 documents found, page 1 of 2
Exploring bio-based alternatives to cyclopentasiloxane: paving the way to promi...
Castro, Mariana; Roque, Catarina; Loureiro, Ana Isabel Sá; Guimarães, Diana Isabel Pereira; Silva, C.; Ribeiro, Artur; Cavaco-Paulo, ArturIn recent years, significant efforts have been made to identify suitable alternatives for silicones commonly used in daily cosmetic products. However, green alternatives have faced challenges in replicating the unique properties of silicone-based formulations, particularly cyclopentasiloxane, which continues to be widely used.This study explores the potential of six biosynthesized esters (heptyl heptanoate, hep...
Physicochemical properties of new silicone alternatives unraveled by experiment...
Ferreira, Tiago; Rocha, Diana; Freitas, David Silva; Noro, Jennifer Martins; Castro, Mariana de; Roque, Catarina; Guimarães, Diana Isabel PereiraThe cosmetic industry has recognized an increasing demand for environmentally sustainable solutions due to the classification of certain commonly used components as bioaccumulative and hazardous. The European Union has implemented restrictions on the utilization of some components, including silicones, which limit their concentration. The present investigation intends to find new solutions for cosmetic formulat...
Folate-targeted liposomal formulations improve effects of methotrexate in murin...
Guimarães, Diana Isabel Pereira; Lager, Franck; Renault, Gilles; Guezguez, Jamil; Burnet, Michael; Cunha, Joana; Cavaco-Paulo, Artur; Nogueira, EugéniaMethotrexate (MTX) is first-line therapy for the treatment of rheumatoid arthritis (RA), however, its use may be limited by side effects notably post-injection malaise. When patients are intolerant or become unresponsive, second-line or antibody therapy may be indicated. A folate-targeted liposomal formulation of MTX (FL-MTX) is tropic to arthritic paws and prevents the onset of collagen-induced arthritis (CIA)...
Development of liposomal formulations for therapeutic applications
Guimarães, Diana Isabel PereiraOs lipossomas são considerados um sistema de entrega adequado para vários fármacos. O nosso grupo de investigação desenvolveu uma formulação lipossomal com metotrexato (MTX), a primeira linha de tratamento da artrite reumatoide (AR). Os lipossomas têm uma estratégia inovadora de direcionamento por folato, recorrendo a um péptido hidrofóbico, que tem como alvo o recetor de folato β presente na superfície de macr...
Design of liposomes as drug delivery system for therapeutic applications
Guimarães, Diana Isabel Pereira; Cavaco-Paulo, Artur; Nogueira, E.Liposomes are spherical vesicles consisting of one or more concentric phospholipid bilayers enclosing an aqueous core. Being both nontoxic and biodegradable, liposomes represent a powerful delivery system for several drugs. They have improved the therapeutic efficacy of drugs through stabilizing compounds, overcoming obstacles to cellular and tissue uptake and increasing drug biodistribution to target sites in ...
Comparing the delivery to the hair bulb of two fluorescent molecules of distinc...
Costa, Cristiana; Fernandes, Bruno Pacheco; Guimarães, Diana Isabel Pereira; Nogueira, Eugénia; Martins, Madalena; Matamá, Maria Teresa Gonçalves MacedoThe follicular route is an important drug penetration pathway in any topical application, either concerning dermatological and cosmetic skin treatments or any transdermal administration regimen. Efficient transport into follicles will depend on drug inherent properties but also on the chosen vehicle. The main study goal was to compare several systems for the delivery to the hair bulb of two fluorescent molecule...
Increased encapsulation efficiency of methotrexate in liposomes for rheumatoid ...
Guimarães, Diana Isabel Pereira; Noro, Jennifer Martins; Loureiro, Ana Isabel Sá; Lager, Franck; Renault, Gilles; Cavaco-Paulo, Artur; Nogueira, EugéniaMethotrexate (MTX) is a common drug used to treat rheumatoid arthritis. Due to the excessive side effects, encapsulation of MTX in liposomes is considered an effective delivery system, reducing drug toxicity, while maintaining its efficacy. The ethanol injection method is an interesting technique for liposome production, due to its simplicity, fast implementation, and reproducibility. However, this method occas...
Method for production of liposomes
Guimarães, Diana Isabel Pereira; Nogueira, Eugénia; Cavaco-Paulo, ArturThe present disclosure relates to a method for production of liposomes, in order to obtain high encapsulation efficiency of encapsulated agents with a reduced number of production steps, namely avoiding the extrusion step of the classical liposomal production process. The liposomes of the invention are intended to carry a therapeutic agent like an anticancer agent, antioxidant, anti-inflammatory, antipyretic, a...
Quantification of drugs encapsulated in liposomes by 1H NMR
Guimarães, Diana Isabel Pereira; Noro, Jennifer Martins; Loureiro, Ana Isabel Sá; Cavaco-Paulo, Artur; Nogueira, Eugénia Sofia CostaLiposomes are one of the most important and extensively studied drug delivery system due to their ability to encapsulate different kinds of drugs. Exploiting the advantages of 1H Nuclear Magnetic Resonance (NMR) spectrometry, we established a rapid and easy method for quantification of drugs encapsulated in liposomes. An internal standard, pyridine, was used for quantitative determination of drug concentration....
Protective effect of saccharides on freeze-dried liposomes encapsulating drugs
Guimarães, Diana Isabel Pereira; Noro, Jennifer Martins; Silva, Carla; Cavaco-Paulo, Artur; Nogueira, E.The production of freeze-dried liposomes encapsulating drugs is considered a key challenge since the drugs are prone to leakage. The aim of this work was to study the effect of different saccharides on preserving the stability and drug retention capacity of a previously developed liposomal formulation, when subjected to a freeze-drying process. The protective role of trehalose, lactose, glucose, mannitol and su...