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Large-scale genomic analysis shows association between homoplastic genetic vari...
Ruesen, Carolien; Chaidir, Lidya; van Laarhoven, Arjan; Dian, Sofiati; Ganiem, Ahmad Rizal; Guimarães, Hanna Nebenzahl; Huynen, Martijn A.Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant.
A genomic exploration of transmissibility in Mycobacterium tuberculosis
Guimarães, Hanna NebenzahlThe ability of Mycobacterium tuberculosis (Mtb) to be transmitted from host to host is not well understood. Previous molecular epidemiology studies have shown that while some clinical strains of Mtb are able to cause infection and disease in a large number of individuals exposed to them, others are confined in their transmission, despite the ample chance for the spread of the infection. Since preventing transmi...
Transmission and progression to disease of Mycobacterium tuberculosis phylogene...
Guimarães, Hanna Nebenzahl; Verhagen, Lilly M.; Borgdorff, Martien W.; Van Soolingen, DickThe aim of this study was to determine if mycobacterial lineages affect infection risk, clustering, and disease progression among Mycobacterium tuberculosis cases in The Netherlands. Multivariate negative binomial regression models adjusted for patient-related factors and stratified by patient ethnicity were used to determine the association between phylogenetic lineages and infectivity (mean number of positive...
To be or not to be a pseudogene: a molecular epidemiological approach to the mc...
Santos, Catarina lopes; Guimarães, Hanna Nebenzahl; Mendes, Marta Vaz; Soolingen, Dick van; Neves, Margarida CorreiaTuberculosis presents a myriad of symptoms, progression routes and propagation patterns not yet fully understood. Whereas for a long time research has focused solely on the patient immunity and overall susceptibility, it is nowadays widely accepted that the genetic diversity of its causative agent, Mycobacterium tuberculosis, plays a key role in this dynamic. This study focuses on a particular family of genes, ...
Systematic review of allelic exchange experiments aimed at identifying mutation...
Guimarães, Hanna Nebenzahl; Jacobson, Karen R.; Farhat, Maha R.; Murray, Megan B.BACKGROUND: Improving our understanding of the relationship between the genotype and the drug resistance phenotype of Mycobacterium tuberculosis will aid the development of more accurate molecular diagnostics for drug-resistant tuberculosis. Studies that use direct genetic manipulation to identify the mutations that cause M. tuberculosis drug resistance are superior to associational studies in elucidating an in...
A novel approach : the propensity to propagate (PTP) method for controlling for...
Guimarães, Hanna Nebenzahl; Borgdorff, Martien W.; Murray, Megan B.; Van Soolingen, DickRATIONALE: Understanding the genetic variations among Mycobacterium tuberculosis (MTB) strains with differential ability to transmit would be a major step forward in preventing transmission. OBJECTIVES: To describe a method to extend conventional proxy measures of transmissibility by adjusting for patient-related factors, thus strengthening the causal association found with bacterial factors. METHODS: Clinical,...