2 documents found, page 1 of 1
The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance
Xavier, CPR; Caires, HR; Barbosa, MAG; Bergantim, R; Guimarães, JE; Vasconcelos, MHExtracellular vesicles (EVs) mediate intercellular signaling and communication, allowing the intercellular exchange of proteins, lipids, and genetic material. Their recognized role in the maintenance of the physiological balance and homeostasis seems to be severely disturbed throughout the carcinogenesis process. Indeed, the modus operandi of cancer implies the highjack of the EV signaling network to support tu...
Multiple myeloma: Available therapies and causes of drug resistance
Pinto, V; Bergantim, R; Caires, HR; Seca, H; Guimarães, JE; Vasconcelos, MHMultiple myeloma (MM) is the second most common blood cancer. Treatments for MM include corticosteroids, alkylating agents, anthracyclines, proteasome inhibitors, immunomodulatory drugs, histone deacetylase inhibitors and monoclonal antibodies. Survival outcomes have improved substantially due to the introduction of many of these drugs allied with their rational use. Nonetheless, MM patients successively relaps...