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Portuguese Consensus for the Evaluation of the Multiple Sclerosis Treatment Res...

Batista, Sónia; Capela, Carlos; Correia, Filipe; Ferreira, João; Guimarães, Joana; Santos, Ernestina; Sá, Maria José

Introduction: Multiple sclerosis management has progressed significantly due to the development of novel treatments. Thus, assessing the patients’ treatment response is essential to optimize therapeutic decisions. This study aimed to establish a national consensus on the assessment and monitoring of the response to multiple sclerosis treatment with disease-modifying therapies. Methods: The Delphi methodology wa...

Date: 2025   |   Origin: SINAPSE

Multiple Sclerosis Disease-Modifying Treatment Algorithms: 2025 Positioning of ...

Capela, Carlos; Santos, Ernestina; Palavra, Filipe; Guimarães, Joana; Cerqueira, João; Vale, José; Sousa, Lívia; Batista, Sónia; Sá, Maria José

Multiple sclerosis (MS) is a chronic autoimmune-mediated neurodegenerative disease characterized by inflammation, demyelination, and axonal/neuronal damage in the central nervous system. In Portugal, the prevalence of MS is approximately 64.4 per 100 000 individuals. It is typically diagnosed in young adults aged 30 to 40, with a higher incidence in women, although it can also affect children/adolescents and th...


Prognostic Factors Associated with Disability in a Cohort of Neuromyelitis Opti...

Moura, João; Samões, Raquel; Sousa, Ana Paula; Figueiroa, Sónia; Mendonça, Teresa; Abreu, Pedro; Guimarães, Joana; Melo, Claúdia; Sousa, Raquel

Introduction: Neuromyelitis optica spectrum disorders (NMOSD) and MOG-associated disease (MOGAD) are an increasingly recognized group of demyelinating disorders of the central nervous system. Previous studies suggest that prognosis is predicted by older age at onset, number of relapses, the severity of the first attack and autoantibody status. Objective: To study prognostic factors associated with disability pr...


Sabão e água ou água e sabão? A diferença que um tradutor humano (ainda) pode f...

Guimarães, Joana; Hüsgen, Thomas

Cientes de que o mundo da tradução profissional é indissociável das conquistas da inteligência artificial e certos de que o tradutor humano pode e deve recorrer às ferramentas de tradução automática e às memórias de tradução para aumentar a sua produtividade, o objetivo do presente trabalho é salientar a importância do tradutor no processo tradutivo e a consequente necessidade de adequação da formação dos joven...


Guidelines for the Diagnosis and Treatment of Spontaneous Intracranial Hypotension

Pinto, Maria João; Braz, Luís; Fonseca, José; Pereira, Paulo; Trigo Barbosa, Paula; Gomes, Armanda; Guimarães, Joana

Spontaneous intracranial hypotension (SIH) is a syndrome characterized by disabling orthostatic headache, due to reduced cerebrospinal fluid (CSF) volume probably caused by a CSF fistula. It affects mostly women of working-age, although it is probably underdiagnosed. The aim of this article is to present a practical approach to the diagnosis and treatment of SIH. After a description of its symptoms and signs, w...

Date: 2023   |   Origin: Acta Médica Portuguesa

The Effect of a Healthy Lifestyle on Preventing and Improving Symptoms in Patie...

Silva, Carlos; Ferreira, Francisca; Santos Coelho, Francisco; Sá, Maria José; Guimarães, Joana

Introduction: Multiple sclerosis (MS) patients expect healthcare professionals to provide them with information on healthy lifestyles. Thus, the purpose of this systematic review is to evaluate and compile measures with scientific evidence related to these lifestyles and to address solutions to the main barriers to their implementation. Methods: Research of articles in the international databases PubMed® and Sc...

Date: 2023   |   Origin: SINAPSE

Sabão e água ou água e sabão? A diferença que um tradutor humano (ainda) pode f...

Guimarães, Joana; Hüsgen, Thomas

The world of professional translation is inextricably linked to the conquests of artificial intelligence (AI), and human translators need to use machine translation tools and translation memories to increase their productivity. The aim of this paper is to highlight the importance of the human translator in the translation process and, consequently, to adapt the training of young translators to the circumstances...


Natural history of familial cerebral cavernous malformation syndrome in childre...

Geraldo, Ana Filipa; Alves, Cesar Augusto P. F.; Luis, Aysha; Tortora, Domenico; Guimarães, Joana; Abreu, Daisy; Reimão, Sofia; Pavanello, Marco

Purpose: There is limited data concerning neuroimaging findings and longitudinal evaluation of familial cerebral cavernous malformations (FCCM) in children. Our aim was to study the natural history of pediatric FCCM, with an emphasis on symptomatic hemorrhagic events and associated clinical and imaging risk factors. Methods: We retrospectively reviewed all children diagnosed with FCCM in four tertiary pediatric...


Spinal involvement in pediatric familial cavernous malformation syndrome

Geraldo, Ana Filipa; Luis, Aysha; Alves, Cesar Augusto P. F.; Tortora, Domenico; Guimarães, Joana; Reimão, Sofia; Pavanello, Marco; de Marco, Patrizia

Purpose: The aim of the study was to assess the prevalence and characteristics of spinal cord cavernous malformations (SCCM) and intraosseous spinal vascular malformations (ISVM) in a pediatric familial cerebral cavernous malformation (FCCM) cohort and evaluate clinico-radiological differences between children with (SCCM +) and without (SCCM-) SCCM. Methods: All patients with a pediatric diagnosis of FCCM evalu...



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