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Gingerol suppresses sepsis-induced acute kidney injury by modulating methylsulf...

Rodrigues, Francisco Adelvane de Paulo; Santos, Alan Diego da Conceição; Medeiros, Pedro Henrique Quintela Soares de; Prata, Mara de Moura Gondim

Acute kidney injury (AKI) and metabolic dysfunction are critical complications in sepsis syndrome; however, their pathophysiological mechanisms remain poorly understood. Therefore, we evaluated whether the pharmacological properties of 6-gingerol (6G) and 10-gingerol (10G) could modulate AKI and metabolic disruption in a rat model of sepsis (faecal peritonitis). Animals from the sham and AKI groups were intrape...

Date: 2018   |   Origin: Oasisbr

[6]-Gingerol e [10]-Gingerol modulam as alterações renais promovidas por modelo...

Rodrigues, Francisco Adelvane de Paulo

Acute renal failure (AFR) is one of the most complicated and critical events during the septic event, manifesting by production of reactive oxygen species (ROS), glomerular and tubular disorders, which contributes to worsening the prognosis and decreases in survival. [6]-gingerol and [10]-gingerol phenolic compounds are bioactive substances from ginger (Zingiber officinale Rosc.). Such compounds own protective ...

Date: 2017   |   Origin: Oasisbr

[6] - Gingerol isolado do gengibre (zingiber officinale roscoe) modula as alter...

Candido, Pedro Mateus Sales de Oliveira; Rodrigues, Francisco Adelvane de Paulo; Silva, James Almada da; Rodrigues, Tamara Silva; Binda, Alexandre Havt

CANDIDO, Pedro Mateus Sales de Oliveira;RODRIGUES, Francisco Adelvane de Paulo;SILVA, James Almada da; RODRIGUES, Tamara Silva;BINDA, Alexandre Havt. [6] - Gingerol isolado do gengibre (zingiber officinale roscoe) modula as alterações renais causadas pela septicemia induzida em modelo animal. Revista Encontros Universitários da UFC, Fortaleza, v. 1, n. 1, 2016. (Encontro de Iniciação Científica, 35); O presente...

Date: 2017   |   Origin: Oasisbr

Efeito antibacteriano e antifúngico de extratos etanólico, hexânico e metanólic...

Santana, Paloma de Souza; Andreza, Raul Sousa; Leite, Vivianne Inácio; Sousa, Priscila Caracas Vieira de; Alves, Amanda Aragão; Tintino, Saulo Relison

The infections caused by bacteria and fungi, as well as the subsequent resistance of these microorganisms continue with high incidencesthus studies of medicinal plants and their combination with conventional therapy, are becoming essential. This study examined the antibacterial, antifungal and modifier of resistance to antibiotics and antifungal extracts of ethanol, hexane and methanol from the leaves of Kalanc...

Date: 2016   |   Origin: Oasisbr

Efeitos da fração ZOEB4 contendo o [6]-, [8]- E [10]-gingerol isolados do gengi...

Rodrigues, Francisco Adelvane de Paulo

A Gentamicina (GM) é um aminoglicosídeo amplamente utilizado contra infecções por microrganismos gram-negativos. Lesão renal aguda (LRA) é a principal limitação para a sua eficácia terapêutica, ocorrendo em 10-20% dos pacientes. O evento capital é produção de espécies reativa de oxigênio (EROs) e alteração na dinâmica intra-renal e glomerular. O gengibre é fonte de substâncias bioativas que podem ter efeito sat...

Date: 2014   |   Origin: Oasisbr

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