4 documents found, page 1 of 1
Differential effects of antigens from L. braziliensis isolates from disseminate...
Leopoldo, Paulo de Tarso Gonçalves; Almeida, Roque Pacheco de; Schriefer, Albert; Giudice, Ângela; Jesus, Amélia Maria Ribeiro de; Ho, JohnBACKGROUND: Disseminated leishmaniasis is an emerging infectious disease, mostly due to L. braziliensis, which has clinical and histopathological features distinct from cutaneous leishmaniasis. METHODS: In the current study we evaluated the in vitro production of the cytokines IFN-γ, TNF-α, IL-5 and IL-10 by peripheral blood mononuclear cells (PBMC) from 15 disseminated leishmaniasis and 24 cutaneous leishmania...
CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasi...
Léa, Castellucci; Jamieson, Sarra Elisabeth; Miller, E. Nancy; Menezes, Eliane; Oliveira, Joyce; Guimarães, Luiz Henrique Santos; Lessa, MarcusBACKGROUND: L. braziliensis causes cutaneous (CL) and mucosal (ML) leishmaniasis. Wound healing neutrophil (PMN) and macrophage responses made following the bite of the vector sand fly contribute to disease progression in mice. To look at the interplay between PMN and macrophages in disease progression in humans we asked whether polymorphisms at genes that regulate their infiltration or function are associated ...
Resistance of Leishmania (Viannia) braziliensis to nitric oxide: correlation wi...
Souza, Anselmo; Giudice, Ângela; Pereira, Júlia M. B.; Guimarães, Luiz Henrique Santos; Jesus, Amélia Maria Ribeiro de; Moura, Tatiana Rodrigues deBACKGROUND: Nitric oxide (NO) produced in macrophages plays a pivotal role as a leishmanicidal agent. A previous study has demonstrated that 20% of the L. (V.) braziliensis isolated from initial cutaneous lesions of patients from the endemic area of Corte de Pedra, Bahia, Brazil, were NO resistant. Additionally, 5 to 11% of the patients did not respond to three or more antimony treatments" (refractory patients)...
Multiclonal Leishmania braziliensis Population Structure and Its Clinical Impli...
Schriefer, Nicolaus Albert Borges; Góes Neto, Aristóteles; Almeida, Roque Pacheco de; Carvalho, Lucas Pedreira de; Machado, Paulo Roberto Limap. 508–514; Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2011-12-11T17:03:46Z No. of bitstreams: 1 1077.pdf: 1159272 bytes, checksum: 42eaf0f40906bf9b35739de038ee64f2 (MD5); Made available in DSpace on 2011-12-11T17:03:46Z (GMT). No. of bitstreams: 1 1077.pdf: 1159272 bytes, checksum: 42eaf0f40906bf9b35739de038ee64f2 (MD5) Previous issue date: 2004-01; In Corte de Pedra (CP), northeas...