Encontrados 5 documentos, a visualizar página 1 de 1
Resilience and susceptibility to neuropathic pain manifestation
Guimarães, Marco Rafael MachadoA maioria dos indivíduos que desenvolve dor após uma lesão retorna ao estado saudável quando a lesão dissipa. Por outro lado, numa pequena percentagem de pessoas a dor persiste por longos períodos e evolui para dor crónica (DC), geralmente acompanhada por comorbidades emocionais e cognitivas. Nos animais, a DC também é caracterizada pelos mesmas comorbidades. Todavia, os mecanismos neuronais que intervêm na tra...
Evidence for lack of direct causality between pain and affective disturbances i...
Guimarães, Marco Rafael Machado; Soares, Ana R.; Cunha, Ana M.; Esteves, Madalena; Borges, Sónia; Magalhães, Ricardo José SilvaChronic pain is frequently accompanied by the manifestation of emotional disturbances and cognitive deficits. While a causality relation between pain and emotional/cognitive disturbances is generally assumed, several observations suggest a temporal dissociation and independent mechanisms. We therefore studied Sprague-Dawley rats that presented a natural resistance to pain manifestation in a neuropathy model (sp...
Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats
Soares, Ana Rosa; Esteves, Madalena; Moreira, Pedro Miguel Silva; Cunha, Ana Margarida; Guimarães, Marco Rafael Machado; Carvalho, Miguel MurteiraImpulsivity is a naturally occurring behavior that, when accentuated, can be found in a variety of neuropsychiatric disorders. The expression of trait impulsivity has been shown to change with a variety of factors, such as age and sex, but the existing literature does not reflect widespread consensus regarding the influence of modulating effects. We designed the present study to investigate, in a cohort of sign...
Pawedness trait test (PaTRaT) : a new paradigm to evaluate paw preference and d...
Cunha, Ana M.; Esteves, Madalena Curva; Neves, Sofia Pereira; Borges, Sónia Maria de Sousa; Guimarães, Marco Rafael Machado; Sousa, NunoIn rodents, dexterity is commonly analyzed in preference paradigms in which animals are given the chance to use either the left or the right front paws to manipulate food. However, paw preference and dexterity at population and individual levels are controversial as results are incongruent across paradigms. We have therefore developed a semi-quantitative method-the pawdeness trait test (PaTRaT)-to evaluate paw ...
Leucine-Rich repeat kinase 2 (LRRK2) in Parkinson’s Disease - a role in endocyt...
Guimarães, Marco Rafael MachadoDissertação de mestrado em Biologia Celular e Molecular. apresentada ao Departamento Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra.; A doença de Parkinson (PD) é uma perturbação cerebral e prolongada que se caracteriza pelo inclusão de corpos de Lewy (LB) e pela degeneração dos neurónios dopaminérgicos da substância nigra pars compacta (SNpc) até ao estriado. É a segunda doen...