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Preliminary chemical profile and in vitro pharmacological evaluation of the hal...
Garcia, Maria Rita; Dutka, Mykhaylo; Guimarães, Sofia; Andrade, Paula B.; Seabra, Vítor; Dias-da-Silva, DianaBackground: For the last few years, Ayahuasca ceremonies have been gaining popularity in recreational settings in Europe and North America [1]. Similar to Psychotria viridis, Diplopterys cabrerana is also suggested to contain the psychoactive compound N,N-dimethyltryptamine, and is therefore used in Ayahuasca rituals for its ability to induce hallucinations, euphoria and entheogenic effects [1-3]. However, whil...
Preliminary chemical profile and in vitro pharmacological evaluation of the hal...
Garcia, Maria Rita; Dutka, Mykhaylo; Guimarães, Sofia; Andrade, Paula B.; Seabra, Vítor; Diana Dias da Silva; Gomes, Nelson G. M.For the last few years, Ayahuasca ceremonies have been gaining popularity in recreational settings in Europe and North America [1]. Similar to Psychotria viridis, Diplopterys cabreranais also suggested to contain the psychoactive compound N,N-dimethyltryptamine, and is therefore used in Aya-huasca rituals for its ability to induce hallucinations, euphoria and entheogenic effects [1-3]. However, while informatio...
Amyloid precursor protein interaction network in human testis: sentinel protein...
Silva, Joana Vieira; Yoon, Sooyeon; Domingues, Sara; Guimarães, Sofia; Goltsev, Alexander V.; Silva, Edgar Figueiredo da Cruz eBackground Amyloid precursor protein (APP) is widely recognized for playing a central role in Alzheimer's disease pathogenesis. Although APP is expressed in several tissues outside the human central nervous system, the functions of APP and its family members in other tissues are still poorly understood. APP is involved in several biological functions which might be potentially important for male fertility, such...