4 documents found, page 1 of 1
Adenosine A2A receptors control the extracellular levels of adenosine through m...
Pinto-Duarte, António; Coelho, Joana E.; Cunha, Rodrigo A.; Ribeiro, Joaquim Alexandre; Sebastião, Ana M.Adenosine, a neuromodulator of the CNS, activates inhibitory-A1 receptors and facilitatory-A2A receptors; its synaptic levels are controlled by the activity of bi-directional equilibrative nucleoside transporters. To study the relationship between the extracellular formation/inactivation of adenosine and the activation of adenosine receptors, we investigated how A1 and A2A receptor activation modifies adenosine...
Adenosine A2A receptors control the extracellular levels of adenosine through m...
Duarte, António Pinto; Coelho, Joana E.; Cunha, Rodrigo A.; Ribeiro, Joaquim Alexandre; Sebastião, Ana MAdenosine, a neuromodulator of the CNS, activates inhibitory- A1 receptors and facilitatory-A2A receptors; its synaptic levels are controlled by the activity of bi-directional equilibrative nucleoside transporters. To study the relationship between the extracellular formation/inactivation of adenosine and the activation of adenosine receptors, we investigated how A1 and A2A receptor activation modifies adenosin...
Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA relea...
Canas, Nuno; Pereira, Inês T.; Ribeiro, Joaquim Alexandre; Sebastião, Ana MBrain-derived neurotrophic factor (BDNF) has an acute excitatory effect on rat hippocampal synaptic transmission. To compare the action of BDNF upon the release of excitatory and inhibitory neurotransmitters in the hippocampus, we studied the effect of acutely applied BDNF on the K+ -evoked glutamate and on the K+ -evoked y-aminobutyric acid (GABA) release from rat hippocampal nerve terminals (synaptosomes). Th...
Endogenous Adenosine Modulation of 22Na Uptake by Rat Brain Synaptosomes
Ribeiro, Joaquim Alexandre; Lobo, M. Graça B.; Sebastião, Ana M.To evaluate if endogenous extracellular adenosine influences sodium channel activity in nerve terminals, we investigated how manipulations of extracellular adenosine levels influence 22Na uptake by rat brain synaptosomes stimulated with veratridine (VT). To decrease extracellular adenosine levels, adenosine deaminase (ADA) that converts adenosine into an inactive metabolite was used. To increase extracellular a...