2 documents found, page 1 of 1
One-Pot Microfluidics to Engineer Chitosan Nanoparticles Conjugated with Antimi...
Fonseca, D R; Alves, PM; Neto, E; Custodio, B; Guimaraes, S; Moura, D; Annis, F; Martins, M; Gomes, A; Teixeira, C; Gomes, P; Pereira, RF; Freitas, PSurface bioconjugation of antimicrobial peptides (AMP) onto nanoparticles (AMP-NP) is a complex, multistep, and time-consuming task. Herein, a microfluidic system for the one-pot production of AMP-NP was developed. Norbornene-modified chitosan was used for NP production (NorChit-NP), and thiolated-AMP was grafted on their surface via thiol-norbornene "photoclick" chemistry over exposure of two parallel UV LEDs....
Evaluation of fibrosis and inflammation in diffuse liver diseases using intravo...
França, M; Martí-Bonmatí, L; Alberich-Bayarri, Á; Oliveira, P; Guimaraes, S; Oliveira, J; Amorim, J; Gonzalez, JS; Vizcaíno, JR; Miranda, HPPurpose: The purpose of the study was to evaluate the role of intravoxel incoherent motion (IVIM) diffusion model for the assessment of liver fibrosis and inflammation in diffuse liver disorders, also considering the presence of liver steatosis and iron deposits. Methods: Seventy-four patients were included, with liver biopsy and a 3 Tesla abdominal magnetic resonance imaging examination, with an IVIM diffusion...