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Probe-based metagenomic pathogen detection
Ferreira, Rita; Coelho, Luís; Santos, João Dourado; Sobral, Daniel; Isidro, Joana; Mixão, Verónica; Pinto, Miguel; Nunes, Alexandra; Borrego, Maria JoséPublisher Copyright: Copyright © 2025 Ferreira, Coelho, Santos, Sobral, Isidro, Mixão, Pinto, Nunes, Borrego, Lopo, Oleastro, Sousa, Palminha, Veríssimo, Gargaté, Guiomar, Cordeiro, Macedo, Bajanca-Lavado, Paixão, Duarte, Vieira, Borges and Gomes.; Probe-based pathogen enrichment, followed by NGS, is a promising tool for complex diagnosis, overcoming traditional challenges of shotgun metagenomics, namely small ...
Immune response against influenza in a cohort of repeatedly vaccinated adults d...
Guiomar, Raquel; Silva, Susana Pereira da; Rodrigues, Ana Paula; Costa, Inês; Conde, Patrícia; Cristóvão, Paula; Pechirra, Pedro; Estragadinho, PauloFunding Information: We would like to acknowledge all the participants from the staff of the National Institute of Health for their participation in the present study and their donation of blood samples for the evaluation of the humoral immunity response after vaccination during 2017/2018 and 2018/2019 seasons. We acknowledge Anabela Cordeiro, assistant at the Department of Occupational Medicine, National Insti...
Monitoring COVID-19 and influenza
Torres, Ana Rita; Gómez, Verónica; Kislaya, Irina; Rodrigues, Ana Paula; Fernandes Tavares, Margarida; Pereira, Ana Catarina; Pereira, DéboraPublisher Copyright: Copyright © 2023 Ana Rita Torres et al.; Background. Severe acute respiratory infections (SARI) surveillance is recommended to assess the severity of respiratory infections disease. In 2021, the National Institute of Health Doutor Ricardo Jorge, in collaboration with two general hospitals, implemented a SARI sentinel surveillance system based on electronic health registries. We describe its...
Effectiveness of complete primary vaccination against COVID-19 at primary care ...
Kissling, Esther; Hooiveld, Mariette; Martinez-Baz, Ivan; Mazagatos, Clara; William, Naoma; Vilcu, Ana Maria; Kooijman, Marjolein N.; Ilic, MajaFunding Information: This project received funding from the European Centre for Disease Prevention and Control (ECDC) under the contract ECD.11486. Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101003673. Publisher Copyright: © 2022 European Centre for Disease Prevention and Control (ECDC). All rights rese...
Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolu...
Amicone, Massimo; Borges, Vítor; Alves, Maria João; Isidro, Joana; Zé-Zé, Líbia; Duarte, Sílvia; Vieira, Luís; Guiomar, Raquel; Gomes, João PauloFunding: M.A. was supported by ‘Fundação para a Ciência e Tecnologia’ (FCT), fellowships PD/BD/138735/2018. Research was supported by FCT Project PTDC/BIA-EVL/31528/2017 to I.G. and by funds from Portuguese NIH.; Background and objectives: To understand how organisms evolve, it is fundamental to study how mutations emerge and establish. Here, we estimated the rate of mutation accumulation of SARS-CoV-2 in vitro...
Nosocomial Outbreak of SARS-CoV-2 in a "Non-COVID-19" Hospital Ward
Borges, Vítor; Isidro, Joana; Macedo, Filipe; Neves, José; Silva, Luís; Paiva, Mário; Barata, José; Catarino, Judite; Ciobanu, Liliana; Duarte, SílviaFunding: This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. This work is also a result of the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Progr...
Respiratory infections in elderly people
Chasqueira, Maria-Jesus; Paixão, Paulo; Rodrigues, Maria-Lúcia; Piedade, Cátia; Caires, Iolanda; Palmeiro, Teresa; Botelho, Maria-AmaliaThis work was supported by Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia - FCT, grant number PTDC/SAU-SAP/116563/2010) through Operational Competitiveness Programme (COMPETE) as part of the National Strategic Reference Framework.; OBJECTIVE: the aim of this study was to analyze the etiology and clinical consequences of viral respiratory infections in 18 elderly care centers (ECC) i...
Hospitalization Risk Due to Respiratory Illness Associated with Genetic Variati...
Gaio, Vania; Nunes, Baltazar; Pechirra, Pedro; Conde, Patricia; Guiomar, Raquel; Dias, Carlos Matias; Barreto, MartaBackground Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection. However, it is not clear whether the reported association relates to influenza infection severity. The aim of this study was to estimate the hospitalization risk associated with this variant in Influenza Like Illness (ILI) patients during the H1N1 pand...