205 documents found, page 1 of 21
Cross-sectional study on protective antibodies against influenza A virus subtyp...
Guiomar, Raquel; Henriques, Camila; Pereira da Silva, Susana; Gomes, Licínia; Dias, Daniela; Verdasca, NunoThe 2025/26 season was marked by co-circulation of influenza A subtypes, with the first detection of A(H3N2) subclade K in September 2025. In August 2025 in Portugal, 14.8% (95% CI: 12.2-17.8) of 886 persons tested had cross-protective antibodies against this subclade. The overall seroprevalence against circulating A(H1N1)pdm09 strains was 28.1% (95% CI: 24.4-32.0). These data highlight the presence of previous...
Testes rápidos de antigénio e efetividade da vacina contra a COVID-19 nos cuida...
Gómez, Verónica; Delaunay, Charlotte Laniece; Kissling, Esther; Verdasca, Nuno; Gomes, Licínia; Guiomar, Raquel; Machado, Ausenda; Rodrigues, Ana PaulaA disponibilização dos testes rápidos de antigénio (TRAg) permitiu que o diagnóstico de infeção por SARS-CoV-2 possa ser feito antes ou durante uma consulta médica. Este conhecimento pode condicionar a procura de cuidados e por outro lado, o Médico de Família (MF) pode ter informação sobre o estado de infeção antes do recrutamento do doente para os estudos de efetividade vacinal. Estudos com desenho de caso-con...
RSV-Bacterial Co-Infection Is Associated With Increased Illness Severity in Hos...
Torres, Ana Rita; Gaio, Vânia; Melo, Aryse; Lança, Miguel; Barreto, Marta; Lagoa Gomes, Licínia Isabel; Azevedo, Inês; Bandeira, Teresa; Lito, DavidDuring the autumn/winter respiratory syncytial virus (RSV) epidemics, bacterial co-infection is common and affects the disease severity. We aimed to understand the relationship between RSV-bacterial co-infections and clinical severity since the RSV seasonality change after COVID-19 pandemic. We conducted a prospective, sentinel surveillance study at 20 sites in Portugal in children under 2 years hospitalized wi...
Seroprevalência de SARS-CoV-2 em profissionais de saúde de hospitais em compara...
Gaio, Vânia; Amaral, Palmira; Santos, Ana João; Henriques, Camila; Guiomar, Raquel; Rodrigues, Ana Paula; Machado, AusendaOs profissionais de saúde (PS) desempenham um papel essencial na linha de frente durante emergências de saúde causadas por doenças infeciosas. Protegê-los é crucial para garantir a sua saúde, manter a continuidade do atendimento aos pacientes e prevenir a transmissão durante a prestação de cuidados. Este estudo teve como objetivo estimar a tendência da seroprevalência de SARS-CoV-2 entre PS de uma coorte hospit...
Recommendations for estimating and reporting vaccine effectiveness by time sinc...
Kissling, Esther; Nunes, Baltazar; Hooiveld, Mariëtte; Martínez-Baz, Iván; Monge, Susana; Robertson, Chris; Knolm, Mirjam; Sève, Noémie; Mlinarić, IvanEstimating COVID-19 vaccine effectiveness (VE) by time since vaccination (TSV) is essential for understanding how protection may change over time and enables meaningful comparisons across studies. This is important for accurate comparisons of VE against different SARS-CoV-2 variants/sublineages, across age groups, during different periods post vaccination campaign, or by vaccine type/brand. We provide recommend...
Influenza vaccine effectiveness in Europe and the birth cohort effect against i...
Kissling, Esther; Maurel, Marine; Pozo, Francisco; Pérez-Gimeno, Gloria; Buda, Silke; Sève, Noémie; Domegan, Lisa; Hooiveld, Mariëtte; Oroszi, BeatrixIntroduction: Influenza A(H1N1)pdm09, A(H3N2) and B/Victoria viruses circulated in Europe in 2023/24, with A(H1N1)pdm09 dominance. First influenza infections in childhood may lead to different vaccine effectiveness (VE) in subsequent years. Aim: The VEBIS primary care network estimated influenza VE in Europe using a multicentre test-negative study. Methods: Primary care practitioners collected information and s...
The potential bias introduced into COVID-19 vaccine effectiveness studies at pr...
Lanièce Delaunay, Charlotte; Nunes, Baltazar; Monge, Susana; de Lange, Marit; Túri, Gergő; Machado, Ausenda; Latorre-Margalef, Neus; Mlinarić, IvanBackground: With SARS-CoV-2 self-tests, persons with acute respiratory infections (ARI) can know their COVID-19 status. This may alter their decision to consult a general practitioner (GP), potentially biasing COVID-19 vaccine effectiveness (VE) studies. We explore bias mechanisms, simulate magnitude, and verify control methods. Methods: We used directed acyclic graphs (DAGs) to illustrate the bias mechanisms. ...
RSV-Bacterial Co-Infection Is Associated With Increased Illness Severity in Hos...
Torres, Ana Rita; Gaio, Vânia; Melo, Aryse; Lança, Miguel; Barreto, Marta; Gomes, Licínia; Azevedo, Inês; Bandeira, Teresa; Lito, David; Guiomar, RaquelDuring the autumn/winter respiratory syncytial virus (RSV) epidemics, bacterial co-infection is common and affects the disease severity. We aimed to understand the relationship between RSV-bacterial co-infections and clinical severity since the RSV seasonality change after COVID-19 pandemic. We conducted a prospective, sentinel surveillance study at 20 sites in Portugal in children under 2 years hospitalized wi...
Europe needs a sustainably funded influenza research and response network
Krammer, Florian; Barclay, Wendy S.; Beer, Martin; Brown, Ian H.; Cox, Rebecca Jane; de Jong, Menno D.; Fodor, Ervin; Fouchier, Ron A.M.No abstract available
Effectiveness of long-acting monoclonal antibodies against laboratory-confirmed...
Savulescu, Camelia; Ganser, Iris; Nicolay, Nathalie; Lajot, Adrien; Campos, Sandra; Martínez-Baz, Iván; Rodrigues, Ana Paula; Vandromme, MathilWe measured effectiveness of nirsevimab against laboratory-confirmed respiratory syncytial virus (RSV) infection in a test-negative case-control study among children aged < 24 months hospitalised for severe acute respiratory infection in three European countries. The overall effectiveness in the 2024/25 season among 2,201 children was 79% (95% CI: 58 to 89) and 85%, 78% and 69% at < 30, 30-89 and 90-215 days si...