2 documents found, page 1 of 1
Pericardial fluid accumulates microRNAs that regulate heart fibrosis after myoc...
Silva, Elsa D.; Pereira-Sousa, Daniel; Ribeiro-Costa, Francisco; Cerqueira, Rui; Enguita, Francisco J.; Gomes, Rita N.; Dias-Ferreira, JoãoPericardial fluid (PF) has been suggested as a reservoir of molecular targets that can be modulated for efficient repair after myocardial infarction (MI). Here, we set out to address the content of this biofluid after MI, namely in terms of microRNAs (miRs) that are important modulators of the cardiac pathological response. PF was collected during coronary artery bypass grafting (CABG) from two MI cohorts, pati...
Neonatal Apex Resection Triggers Cardiomyocyte Proliferation, Neovascularizatio...
Sampaio-Pinto, Vasco; Rodrigues, Sílvia C.; Laundos, Tiago L.; Silva, Elsa D.; Vasques-Nóvoa, Francisco; Silva, Ana C.; Cerqueira, Rui J.So far, opposing outcomes have been reported following neonatal apex resection in mice, questioning the validity of this injury model to investigate regenerative mechanisms. We performed a systematic evaluation, up to 180 days after surgery, of the pathophysiological events activated upon apex resection. In response to cardiac injury, we observed increased cardiomyocyte proliferation in remote and apex regions,...