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In vitro and in vivo effects of SerpinA1 on the modulation of Transthyretin pro...
Bezerra, Filipa; Niemietz, Christoph; Schmidt, Hartmut H. J.; Zibert, Andree; Guo, Shuling; Monia, Brett P.; Gonçalves, Paula Isabel MeiraTransthyretin (TTR) proteolysis has been recognized as a complementary mechanism contributing to transthyretin-related amyloidosis (ATTR amyloidosis). Accordingly, amyloid deposits can be composed mainly of full-length TTR or contain a mixture of both cleaved and full-length TTR, particularly in the heart. The fragmentation pattern at Lys48 suggests the involvement of a serine protease, such as plasmin. The mos...
Date: 2021
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Origin: RepositóriUM - Universidade do Minho