4 documents found, page 1 of 1
The fungus Candida albicans tolerates ambiguity at multiple codons
Simões, João; Bezerra, Ana R.; Moura, Gabriela R.; Araújo, Hugo; Gut, Ivo; Bayes, Mónica; Santos, Manuel A. S.The ascomycete Candida albicans is a normal resident of the gastrointestinal tract of humans and other warm-blooded animals. It occurs in a broad range of body sites and has high capacity to survive and proliferate in adverse environments with drastic changes in oxygen, carbon dioxide, pH, osmolarity, nutrients, and temperature. Its biology is unique due to flexible reassignment of the leucine CUG codon to seri...
Detection and characterization of interleukin-6 gene variants in canis familiar...
Morinha, Francisco; Albuquerque, Carlos; Requicha, João; Dias, Isabel R.; Leitão, José; Gut, Ivo; Pinto, Henrique Guedes; Viegas, Carlos A.Periodontal disease (PD) is the most common inflammatory disease of the oral cavity of domestic carnivores. In Human Medicine molecular genetics research showed that several genes play a role in the predisposition and progression of this complex disease, primarily through the regulation of inflammatory mediators, but the exactly mechanisms are poorly understood. This study aims to contribute to the characteriza...
Splicing enhances recruitment of methyltransferase HYPB-Setd2 and methylation o...
de Almeida, Sérgio F.; Grosso, Ana Rita; Koch, Frederic; Fenouil, Romain; Carvalho, Silvia; Andrade, Jorge; Levezinho, Helena; Gut, Marta; Eick, DirkSeveral lines of recent evidence support a role for chromatin in splicing regulation. Here, we show that splicing can also contribute to histone modification, which implies bidirectional communication between epigenetic mechanisms and RNA processing. Genome-wide analysis of histone methylation in human cell lines and mouse primary T cells reveals that intron-containing genes are preferentially marked with histo...
Transcriptome Analysis Describing New Immunity and Defense Genes in Peripheral ...
Teixeira, Vitor Hugo; Olaso, Robert; Martin-Magniette, Marie-Laure; Lasbleiz, Sandra; Jacq, Laurent; Oliveira, Catarina Resende; Hilliquin, PascalBackground: Large-scale gene expression profiling of peripheral blood mononuclear cells from Rheumatoid Arthritis (RA) patients could provide a molecular description that reflects the contribution of diverse cellular responses associated with this disease. The aim of our study was to identify peripheral blood gene expression profiles for RA patients, using Illumina technology, to gain insights into RA molecular...