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Role of HIF-1α signaling pathway in osteoarthritis: a systematic review

Fernández-Torres,Javier; Martínez-Nava,Gabriela Angélica; Gutiérrez-Ruíz,María Concepción; Gómez-Quiroz,Luis Enrique; Gutiérrez,Marwin

Abstract Osteoarthritis (OA) is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvironment devoid of oxygen, which is regulated by hypoxia inducible factor (HIF-1α). HIF-1α is considered the ma...

Date: 2017   |   Origin: Oasisbr
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Escore US7 modificado na avaliação de sinovite em pacientes com artrite reumato...

Mendonça,José Alexandre; Yazbek,Michel Alexandre; Costallat,Beatriz Lavras; Gutiérrez,Marwin; Bértolo,Manoel Barros

Objetivo: Avaliar o escore US7 modificado (escore MUS7 SIN) na avaliação de pacientes com artrite reumatoide inicial (ARI). Além disso, foram examinados recessos dorsais e palmares dos punhos, bem como pequenas articulações das mãos e dos pés, para o diagnóstico de sinovite, mediante uma avaliação global das articulações. Métodos: A amostra do estudo compreendeu 32 pacientes tratados para artrite, com 13 meses ...

Date: 2014   |   Origin: Oasisbr
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