4 documents found, page 1 of 1
Vancomycin-Loaded, Nanohydroxyapatite-Based Scaffold for Osteomyelitis Treatmen...
Alegrete, N; Sousa, SR; Padrão, T; Carvalho, A; Lucas, R; Canadas, RF; Lavrador, C; Alexandre, N; Gärtner, F; Monteiro, FJ; Gutierres, MThe treatment for osteomyelitis consists of surgical debridement, filling of the dead space, soft tissue coverage, and intravenous administration of antimicrobial (AM) agents for long periods. Biomaterials for local delivery of AM agents, while providing controllable antibiotic release rates and simultaneously acting as a bone scaffold, may be a valuable alternative; thus, avoiding systemic AM side effects. V-H...
Local Antibiotic Delivery Ceramic Bone Substitutes for the Treatment of Infecte...
Alegrete, N; Sousa, SR; Peleteiro, B; Monteiro, FJ; Gutierres, MAims: the focus of this study is to evaluate if the combination of an antibiotic with a ceramic biomaterial is effective in treating osteomyelitis in an infected animal model and to define which model and protocol are best suited for in vivo experiments of local bone infection treatment. Methods: a systematic review was carried out based on PRISMA statement guidelines. A PubMed search was conducted to find orig...
Evaluation of cerebral microvascular regulatory mechanisms with transcranial do...
Castro, P; Gutierres, M; Pereira, G; Ferreira, S; Oliveira, JP; Azevedo, EBackground: Fabry disease (FD) causes cerebrovascular disease (CVD) even if asymptomatic, and this is why it is important to identify non-invasive methods to monitor the disease. We evaluated the usefulness of the cerebral autoregulation, vasoreactivity, and neurovascular coupling assessed by transcranial Doppler (TCD) in FD. Methods: Ten adult patients with classic phenotype FD, without clinical expression of ...
Ramp lesions: a systematic review of MRI diagnostic accuracy and treatment effi...
Moreira, J; Almeida, M; Lunet, N; Gutierres, MPurpose. We conducted a systematic review of the published literature to assess the accuracy of Magnetic Resonance Imaging (MRI) in establishing the presence of ramp lesions (RLs) in Anterior Cruciate Ligament (ACL) deficient knees and the clinical efficacy of the surgical repair of RLs. Methods. A comprehensive search of the MEDLINE, Web of Science and Scopus databases was performed according to PRISMA guideli...