12 documents found, page 1 of 2
Why do we Discontinue Biologic Agents? A Retrospective Study of 11 Years
Gil, Francisco; Rato, Margarida; Monteiro, Ana; Parente, Joana; Martins, César; Aranha, João; Silva, Maria JoãoIntroduction: Biologic agents acquired a growing relevance in dermatology, however, adverse events (AE) and reasons to discontinue therapy are not completely known. The objective of this study is to analyse the reasons behind the discontinuation of biologics and characterize the AE in this population of patients. Material and Methods: Descriptive observational study, including patients over 18-years-old under t...
Challenges in characterization of GNSS precise positioning systems for automotive
Pendão, Cristiano Gonçalves; Ferreira, André Filipe Gonçalves; Moreira, Adriano; Martins, César; Silva, Hélder David MalheiroAutonomous driving is currently one of the main focuses of attention in the automotive industry. A requirement for efficient and safe driving of autonomous vehicles is the ability to precisely pinpoint the location of the vehicle, in the decimeter- to centimeter-level on a global scale. GNSS is expected to play a major role in providing accurate absolute and global positioning, yet many challenges arise in dens...
“Life Goes On – Live your Skin!”: A Social Solidarity Project
Monteiro, Ana Filipe; Rato, Margarida; Martins, CésarIntroduction: Premalignant cutaneous lesions, skin cancer, and cutaneous xerosis are diseases whose incidence continues to increase in our older population. Concerning the contest “Dermatologist from the Heart” awarded by Fondation La Roche Posay in 2015, we put into practice the winning project “Life goes on, Live your skin!”. The main purpose of the project was to provide specialized health assistance and pre...
Vemurafenib-Induced Toxic Epidermal Necrolysis: An Emerging Adverse Event
Monteiro, Ana Filipe; Rato, Margarida; Martins, CésarVemurafenib, a selective inhibitor of the BRAF V600 mutation, is Food and Drug Administration and European Medicines Agency approved for the treatment of stage IV metastatic melanoma alone or in combination. Among the adverse effects, cutaneous toxicity is the most common. Most of these reactions such as maculopapular rash, photosensitivity and hyperkeratotic lesions are manageable, and the majority of patients...
Análise da durabilidade e estabilidade dos princípios ativos presentes em subst...
Soares, Patrícia Isabel Martins; Costa, Susana P. G.; Martins, CésarO presente trabalho teve como objetivo o estudo da estabilidade do produto Si Repel Mosquito, produzido pela Smart Inovation, em formulações líquidas para serem aplicadas em tintas e vernizes, em têxteis e em aditivos para a máquina de lavar a roupa, bem como o estudo da durabilidade do princípio ativo na fibra têxtil, após várias lavagens, e na tinta, através da degradação acelerada da mesma. O método de aplic...
RECURRENCE OF MELANOMA FOLLOWING A NEGATIVE SENTINEL LYMPH NODE BIOPSY - A RETR...
Toda-Brito, Helena; Rodrigues, Teresa; Tavares, Ermelindo; Parente, Joana; Martins, César; Ferreira, LuísIntroduction: The sentinel lymph node biopsy is an important tool for staging patients with melanoma, allowing identification of occult regional lymph node involvement and avoidance of unnecessary lymphadenectomies.Objective: To analyze the patterns of recurrence of melanoma in patients with a negative sentinel lymph node biopsy result and identify the clinical and pathological characteristics potentially predi...
VULVAR LICHEN SCLEROSUS – A REVIEW OF 208 CASES
Torres, Ermelindo; Parente, Joana; Almeida, J. C.; Teixeira, José; Martins, César; Aranha, JoãoIntroduction: Lichen sclerosus (LS) is a chronic idiopathic inflammatory disease that preferentially affects the anogenital region and postmenopausal Caucasian women. Aims: Retrospective characterization of patients with vulvar LS diagnosed and treated at our Department (Vulvar Pathology Consultation), between 1986 and 2004. Material and Methods: A total of 208 Caucasians women were included in the study. We co...
BACTERIAL POPULATION ISOLATED IN OVER-INFECTED CHRONIC LEG ULCERS – CHARACTERIZ...
Tavares, Ermelindo; Brito, Helena; Parente, Joana; Pinto, Paula; Martins, CésarIntroduction: The chronic leg ulcers (CLU) are frequent reasons for indiscriminate antibiotics prescribing which has contributed to increase the bacterial resistance to many drugs. Objective: Retrospective characterization of the bacterial population and antimicrobial susceptibility profile in patients with CLU admitted between 2007 and 2011 (5 years). Methods: Review of clinical charts and statistical study of...
VULVAR INFLAMMATORY DERMATOSES
Tavares, Ermelindo; Martins, César; Teixeira, JoséVulvar skin diseases represent a heterogeneous group of skin diseases which display infectious, inflam- matory or malignant nature. The authors conducted a review of epidemiological, etiopathogenic, clínicopathological, therapeutic and prognostic aspects of five vulvar inflammatory skin diseases, namely lichen sclerosus, eczema, psoriasis, lichen planus and Zoon’s vulvitis. Except for the Zoon’s vulvitis, vulva...
DIAGNOSIS AND TREATMENT OF LATENT TUBERCULOSIS IN PSORIASIS PATIENTS SUBMITTED ...
Tavares, Ermelindo; Silva, Sónia; Parente, Joana; Carvalho, José Miguel; Martins, CésarIntroduction: TNF-α plays an important role in immune defense against Mycobacterium tuberculosis and, as such, the risk of reactivation of latent tuberculosis increases with the TNF-blocking agents. Aims: To determine the prevalence of latent tuberculosis in psoriasis patients undergoing TNF-blocking agents, between 2006 and 2009. Assess the established therapy and their complications. Materials and methods: Re...