2 documents found, page 1 of 1
Proteomic changes in the extracellular environment of sea bass thymocytes expos...
Moreira, Catarina; Hétru, Julie; Paiola, Matthieu; Duflot, Aurélie; Chan, Philippe; Vaudry, David; Monsinjon, Tiphaine; Knigge, ThomasThe thymus is an important immune organ providing the necessary microenvironment for the development of a diverse, self-tolerant T cell repertoire, which is selected to allow for the recognition of foreign antigens while avoiding self-reactivity. Thymus function and activity are known to be regulated by sex steroid hormones, such as oestrogen, leading to sexual dimorphisms in immunocompetence between males and ...
Prepubertal gonad investment modulates thymus function: evidence in a teleost fish
Paiola, Matthieu; Moreira, Catarina; Hétru, Julie; Duflot, Aurélie; Pinto, Patrícia; Scapigliati, Giuseppe; Knigge, Thomas; Monsinjon, TiphaineThymus plasticity following gonadectomy or sex hormone replacement has long since exemplified sex hormone effects on the immune system in mammals and, to a lesser extent, in 'lower vertebrates', including amphibians and fish. Nevertheless, the underlying physiological significances as well as the ontogenetic establishment of this crosstalk remain largely unknown. Here, we used a teleost fish, the European sea b...