13 documents found, page 1 of 2

Reaproveitamento de medicamentos para COVID-19: uma visão geral

O vírus SARS-CoV-2 pode ocasionar infecções tanto em animais como em humanos. A COVID-19 é uma doença infecciosa causada por esse vírus e conhecida na atualidade por gerar grande preocupação à nível mundial, visto que possui altas taxas de transmissibilidade e patogenicidade. Por este motivo, estratégias terapêuticas potenciais são analisadas para combater a pandemia de COVID-19. Algumas dessas estratégias tera...

Perfil epidemiológico de pacientes com leucemia mieloide aguda: Uma revisão int...

As leucemias são um grupo de neoplasias malignas caracterizadas pela expansão clonal de células progenitoras hematopoiéticas imaturas presentes no sangue e na medula óssea. São divididas em agudas e crônicas e mieloide e linfoide. Assim, o presente estudo teve como objetivo, no manuscrito enviado ao editor, apresentar o perfil epidemiológico de pacientes com leucemia mieloide aguda. Trata-se de uma revisão inte...

Synergistic effect of sertraline and disulfiram against multidrug resistant bac...

The repositioning of approved drugs is atopic of interest for the academy and the pharmaceutical industry. The synergistic combination of these drugs can be successful in the treatment of infections caused by resistant bacteria. This study aimed to assess the in vitro synergistic antibacterial activity of sertraline and disulfiram and their interaction with ciprofloxacin and sulfamethoxazole/trimethoprim. We de...

Emerging strategies for ESKAPE treatment

The persistent use of antibiotics, self-medication and exposure to hospital infections has led to an increase in multidrug-resistant microorganisms. With this emergence of bacterial multiresistance, six pathogens play an essential role. The term ESKAPE deals with six microorganisms with high multiresistance and virulence: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanni...

Quando tomamos conhecimento/consciência da declaração da OMS do surto do novo c...

Prevalence and profile of antimicrobial sensitivity of microrganisms isolated f...

OBJECTIVE: The objective of this work was to evaluate the prevalence and resistance profile of microorganisms isolated from skin and soft tissue secretions. This type of study, as far as we know, was the first carried out in this hospital with a period of four years and a large number of samples. METHODS: A retrospective observational study of cultures of skin infections collected in a tertiary teaching hospita...

Avaliação da atividade antibacteriana in vitro do medicamento ácido acetilsalic...

Objetivo: Avaliar a atividade antibacteriana do anti-inflamatório ácido acetilsalicílico (AAS) frente seis cepas bacterianas padrão de referência American Type Culture Collection (ATCC) e 41 isolados clínicos multidroga resistentes (MDR). Métodos: A atividade antibacteriana do medicamento foi determinada através da concentração inibitória mínima (CIM) obtida frente às cepas bacterianas. Resultados: AAS demonstr...

Synergistic antibacterial effect of statins with the complex {[1-(4-bromophenyl...

The treatment of infections caused by resistant microorganisms represents a big challenge in healthcare due to limited treatment options. For this reason, the discovery of new active substances which are able to perform innovative and selective actions is of great impact nowadays. Statins and triazenes (TZC) have consolidated as a promising class of compounds, characterized by the expressive biological activity...

Resistance to colistin in isolates of newborn hemocultures admitted in a school...

The objective of this study was to evaluate resistance against colistin in isolates of blood cultures from newborns (NB) admitted in a School Hospital in a 4-year period. The identification tests and antimicrobial susceptibility profiles were performed using automated systems. At the period of this study, 923 blood cultures were positive, 92.09% (850/923) were caused by Gram-positive microorganisms and 7.91% (7...

Antimicrobial susceptibility profile and research of mec A and erm genes in coa...

In recent years, several studies have described the clinical impact of bacterial infection associated with transfusion of platelet concentrates (PCs). Among the blood components, PCs are responsible for the highest rates of bacterial contamination as well as septic transfusion reactions. We assessed antimicrobial susceptibility profile, resistance to methicillin (MRCoNS), and resistance to macrolides, lincosami...