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Rab27a and Rab27b control different steps of the exosome secretion pathway
Ostrowski, M.; Carmo, NB.; Krumeich, S.; Fanget, I.; Raposo, G.; Savina, A.; Moita, CF.; Schauer, K.; Hume, AN.; Freitas, RP.; Goud, B.; Benaroch, P.Exosomes are secreted membrane vesicles that share structural and biochemical characteristics with intraluminal vesicles of multivesicular endosomes (MVEs). Exosomes could be involved in intercellular communication and in the pathogenesis of infectious and degenerative diseases. The molecular mechanisms of exosome biogenesis and secretion are, however, poorly understood. Using an RNA interference (RNAi) screen,...
Date: 2010
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Origin: ARCA - Access to Research and Communication Annals