8 documents found, page 1 of 1
ERN ReCONNET points to consider for treating patients living with autoimmune rh...
Talarico, Rosaria; Ramirez, Giuseppe Alvise; Barreira, Sofia; Cardamone, Chiara; Triggianese, Paola; Aguilera, Silvia; Andersen, Jeanette; Avcin, TadejRecent studies have shown that people who are immunocompromised may inadvertently play a role in spurring the mutations of the virus that create new variants. This is because some immunocompromised individuals remain at risk of getting COVID-19 despite vaccination, experience more severe disease, are susceptible to being chronically infected and remain contagious for longer if they become infected and consideri...
Points to consider: EULAR–UEMS standards for the training of European rheumatol...
Alunno, Alessia; Avcin, Tadej; Haines, Catherine; Ramiro, Sofia; Sivera, Francisca; Badreh, Sara; Baraliakos, Xenofon; Bijlsma, Johannes W. J.Background: Postgraduate rheumatology training programmes are already established at a national level in most European countries. However, previous work has highlighted a substantial level of heterogeneity in the organisation and, in part, content of programmes. Objective: To define competences and standards of knowledge, skills and professional behaviours required for the training of rheumatologists. Methods: ...
Environmental and societal factors associated with COVID-19-related death in pe...
Izadi, Zara; Gianfrancesco, Milena A.; Schmajuk, Gabriela; Jacobsohn, Lindsay; Katz, Patricia; Rush, Stephanie; Ja, Clairissa; Taylor, TiffanyBackground: Differences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally. Methods: In this observational study, we de...
Factors associated with COVID-19-related death in people with rheumatic disease...
Strangfeld, Anja; Schäfer, Martin; Gianfrancesco, Milena A.; Lawson-Tovey, Saskia; Liew, Jean W.; Ljung, Lotta; Mateus, Elsa F.; Richez, ChristopheObjectives: To determine factors associated with COVID-19-related death in people with rheumatic diseases. Methods: Physician-reported registry of adults with rheumatic disease and confirmed or presumptive COVID-19 (from 24 March to 1 July 2020). The primary outcome was COVID-19-related death. Age, sex, smoking status, comorbidities, rheumatic disease diagnosis, disease activity and medications were included as...
Long-term safety and efficacy of patisiran for hereditary transthyretin-mediate...
Adams, David; Polydefkis, Michael; González-Duarte, Alejandra; Wixner, Jonas; Kristen, Arnt V.; Schmidt, Hartmut H.; Berk, John L.Background: Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the transthyretin (TTR) gene. We assessed the safety and efficacy of long-term treatment with patisiran, an RNA interference therapeutic that inhibits TTR production, in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy. Methods: This multicentre, open-label ex...
The impact of COVID-19 on rare and complex connective tissue diseases : the exp...
Talarico, Rosaria; Aguilera, Silvia; Alexander, Tobias; Amoura, Zahir; Antunes, Ana M.; Arnaud, Laurent; Avcin, Tadej; Beretta, LorenzoDuring the COVID-19 pandemic, the need to provide high-level care for a large number of patients with COVID-19 has affected resourcing for, and limited the routine care of, all other conditions. The impact of this health emergency is particularly relevant in the rare connective tissue diseases (rCTDs) communities, as discussed in this Perspective article by the multi-stakeholder European Reference Network on Ra...
Undifferentiated connective tissue disease : state of the art on clinical pract...
Antunes, Margarida; Scirè, Carlo Alberto; Talarico, Rosaria; Alexander, Tobias; Avcin, Tadej; Belocchi, Chiara; Doria, Andrea; Franceschini, FrancoThe term 'undifferentiated connective tissue disease' (UCTD) is generally used to describe clinical entities characterised by clinical and serological manifestations of systemic autoimmune diseases but not fulfilling the criteria for defined connective tissue diseases (CTDs). In this narrative review, we summarise the results of a systematic literature research, which was performed as part of the ERN ReCONNET p...
Idiopathic inflammatory myopathies : state of the art on clinical practice guid...
Meyer, Alain; Scirè, Carlo Alberto; Talarico, Rosaria; Alexander, Tobias; Amoura, Zahir; Avcin, Tadej; Barsotti, Simone; Beretta, LorenzoIdiopathic inflammatory myopathies (IIMs) encompass a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and inflammation, but in antisynthetase syndrome arthritis and interstitial lung disease are more frequent and often inaugurate the disease. Clinical practice guidelines (CPGs) have been proposed for IIMs, but they are sparse and heterogeneous. This work aimed at identifying: i)...