3 documents found, page 1 of 1
Inhibition of Brazilian ZIKV strain replication in primary human placental chor...
Souza,Audrien A.A. de; Torres,Lauana R.; Lima,Lyana R.P.; Paula,Vanessa de; Barros,José J.; Bonecini-Almeida,Maria da Gloria; Waghabi,Mariana CaldasABSTRACT Zika virus (ZIKV) infection during pregnancy is associated with a congenital syndrome. Although the virus can be detected in human placental tissue and sexual transmission has been verified, it is not clear how the virus reaches the fetus. Despite the emerging severity caused by ZIKV infection, no specific prophylactic and/or therapeutic treatment is available. The aim of the present study was to evalu...
Frequency of indeterminate results from an interferon-gamma release assay among...
Oliveira,Sandra Maria do Valle Leone de; Trajman,Anete; Paniago,Anamaria Mello Miranda; Motta-Castro,Ana Rita Coimbra; Ruffino-Netto,AntonioABSTRACT Objective: To evaluate the frequency of and factors associated with indeterminate interferon-gamma release assay (IGRA) results in people living with HIV/AIDS (PLWHA). Methods: We tested 81 PLWHA in the central-west region of Brazil, using the tuberculin skin test and an IGRA. Information on sociodemographic and clinical variables was gathered through the use of questionnaires and from medical records....
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis
Neves,Elizabeth de Souza; Curi,André Luis Land; Albuquerque,Maira Cavalcanti de; Palhano-Silva,Cassius Schnel; Silva,Laura Berriel daINTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS: A case-control study was conducted among 30 patients and 90 controls. ...