5 documents found, page 1 of 1
One Size Does Not Fit All: Developing Common Standards for Outcomes in Early-Ph...
Hall, DA; Hibbert, A; Smith, H; Haider, HF; Londero, A; Mazurek, B; Fackrell, KGood practice in clinical trials advocates common standards for assessing and reporting condition-specific complaints ("outcome domains"). For tinnitus, there is no common standard. The Core Outcome Measures in Tinnitus International Delphi (COMiT'ID) study created recommendations that are relevant to the most common intervention approaches for chronic subjective tinnitus in adults using consensus methods. Here...
Dimensions of tinnitus-related complaints reported by patients and their signif...
Haider, H; Fackrell, K; Kennedy, V; Hall, DAINTRODUCTION: Over 70 million people in Europe and >50 million people in the USA are reported to experience tinnitus (the sensation of noise in the absence of any corresponding sound source). Tinnitus is a multidimensional concept. Individual patients may report different profiles of tinnitus-related symptoms which may each require a tailored management approach and an appropriate measure of therapeutic benefit...
Systematic review of outcome domains and instruments used in clinical trials of...
Hall, DA; Haider, H; Szczepek, AJ; Lau, P; Rabau, S; Jones-Diette, J; Londero, A; Edvall, NK; Cederroth, CR; Mielczarek, M; Fuller, TBACKGROUND: There is no evidence-based guidance to facilitate design decisions for confirmatory trials or systematic reviews investigating treatment efficacy for adults with tinnitus. This systematic review therefore seeks to ascertain the current status of trial designs by identifying and evaluating the reporting of outcome domains and instruments in the treatment of adults with tinnitus. METHODS: Records were...
Toward a Global Consensus on Outcome Measures for Clinical Trials in Tinnitus: ...
Hall, DA; Haider, H; Kikidis, D; Mielczarek, M; Mazurek, B; Szczepek, AJ; Cederroth, CRIn Europe alone, over 70 million people experience tinnitus; for seven million people, it creates a debilitating condition. Despite its enormous socioeconomic relevance, progress in successfully treating the condition is somewhat limited. The European Union has approved funding to create a pan-European tinnitus research collaboration network (2014-2018). The goal of one working group is to establish an internat...
Current-reported outcome domains in studies of adults with a focus on the treat...
Hall, DA; Szczepek, AJ; Kennedy, V; Haider, HINTRODUCTION: In Europe alone, over 70 million people experience tinnitus. Despite its considerable socioeconomic relevance, progress in developing successful treatments has been limited. Clinical effectiveness is judged according to change in primary outcome measures, but because tinnitus is a subjective condition, the definition of outcomes is challenging and it remains unclear which distinct aspects of tinni...